Compile Data Set for Download or QSAR

Found 3 hits of ic50 for monomerid = 223674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human))	BDBM223674 (3-{8-[3-(2- chlorophenyl)morph- olin-4-yl]-6-{[(1r...) Show SMILES C[C@@H](Nc1nc(nc2nc(N3CCOCC3c3ccccc3Cl)n(C[C@H]3CC[C@H](C)CC3)c12)-c1noc(=O)[nH]1)C1CCC1 |r,wU:25.26,1.0,wD:28.30,(-4.39,-1.96,;-3.06,-2.73,;-1.72,-1.96,;-1.72,-.42,;-3.06,.35,;-3.06,1.89,;-1.72,2.66,;-.39,1.89,;1.07,2.36,;1.98,1.12,;3.52,1.12,;4.29,-.22,;5.83,-.22,;6.6,1.12,;5.83,2.45,;4.29,2.45,;3.52,3.78,;1.98,3.78,;1.21,5.12,;1.98,6.45,;3.52,6.45,;4.29,5.12,;5.83,5.12,;1.07,-.13,;1.84,-1.46,;3.18,-2.23,;4.51,-1.46,;5.84,-2.23,;5.84,-3.77,;7.18,-4.54,;4.51,-4.54,;3.18,-3.77,;-.39,.35,;-4.39,2.66,;-5.64,1.75,;-6.88,2.66,;-6.41,4.12,;-7.18,5.45,;-4.87,4.12,;-3.06,-4.27,;-4.15,-5.36,;-3.06,-6.45,;-1.97,-5.36,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.568	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...				US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human))	BDBM223674 (3-{8-[3-(2- chlorophenyl)morph- olin-4-yl]-6-{[(1r...) Show SMILES C[C@@H](Nc1nc(nc2nc(N3CCOCC3c3ccccc3Cl)n(C[C@H]3CC[C@H](C)CC3)c12)-c1noc(=O)[nH]1)C1CCC1 |r,wU:25.26,1.0,wD:28.30,(-4.39,-1.96,;-3.06,-2.73,;-1.72,-1.96,;-1.72,-.42,;-3.06,.35,;-3.06,1.89,;-1.72,2.66,;-.39,1.89,;1.07,2.36,;1.98,1.12,;3.52,1.12,;4.29,-.22,;5.83,-.22,;6.6,1.12,;5.83,2.45,;4.29,2.45,;3.52,3.78,;1.98,3.78,;1.21,5.12,;1.98,6.45,;3.52,6.45,;4.29,5.12,;5.83,5.12,;1.07,-.13,;1.84,-1.46,;3.18,-2.23,;4.51,-1.46,;5.84,-2.23,;5.84,-3.77,;7.18,-4.54,;4.51,-4.54,;3.18,-3.77,;-.39,.35,;-4.39,2.66,;-5.64,1.75,;-6.88,2.66,;-6.41,4.12,;-7.18,5.45,;-4.87,4.12,;-3.06,-4.27,;-4.15,-5.36,;-3.06,-6.45,;-1.97,-5.36,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.936	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...				US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 [17-125] (Homo sapiens (Human))	BDBM223674 (3-{8-[3-(2- chlorophenyl)morph- olin-4-yl]-6-{[(1r...) Show SMILES C[C@@H](Nc1nc(nc2nc(N3CCOCC3c3ccccc3Cl)n(C[C@H]3CC[C@H](C)CC3)c12)-c1noc(=O)[nH]1)C1CCC1 |r,wU:25.26,1.0,wD:28.30,(-4.39,-1.96,;-3.06,-2.73,;-1.72,-1.96,;-1.72,-.42,;-3.06,.35,;-3.06,1.89,;-1.72,2.66,;-.39,1.89,;1.07,2.36,;1.98,1.12,;3.52,1.12,;4.29,-.22,;5.83,-.22,;6.6,1.12,;5.83,2.45,;4.29,2.45,;3.52,3.78,;1.98,3.78,;1.21,5.12,;1.98,6.45,;3.52,6.45,;4.29,5.12,;5.83,5.12,;1.07,-.13,;1.84,-1.46,;3.18,-2.23,;4.51,-1.46,;5.84,-2.23,;5.84,-3.77,;7.18,-4.54,;4.51,-4.54,;3.18,-3.77,;-.39,.35,;-4.39,2.66,;-5.64,1.75,;-6.88,2.66,;-6.41,4.12,;-7.18,5.45,;-4.87,4.12,;-3.06,-4.27,;-4.15,-5.36,;-3.06,-6.45,;-1.97,-5.36,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.77	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...				US Patent US9540377 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X1F
					More data for this Ligand-Target Pair