Compile Data Set for Download or QSAR

Found 5 hits of ic50 for monomerid = 26376   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26376 (4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...) Show SMILES CN1CCC(CC1)Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C26H27F3N6O2/c1-16-6-7-20(32-23(36)17-4-3-5-18(12-17)26(27,28)29)13-22(16)24(37)33-21-14-30-25(31-15-21)34-19-8-10-35(2)11-9-19/h3-7,12-15,19H,8-11H2,1-2H3,(H,32,36)(H,33,37)(H,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26376 (4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...) Show SMILES CN1CCC(CC1)Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C26H27F3N6O2/c1-16-6-7-20(32-23(36)17-4-3-5-18(12-17)26(27,28)29)13-22(16)24(37)33-21-14-30-25(31-15-21)34-19-8-10-35(2)11-9-19/h3-7,12-15,19H,8-11H2,1-2H3,(H,32,36)(H,33,37)(H,30,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM26376 (4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...) Show SMILES CN1CCC(CC1)Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C26H27F3N6O2/c1-16-6-7-20(32-23(36)17-4-3-5-18(12-17)26(27,28)29)13-22(16)24(37)33-21-14-30-25(31-15-21)34-19-8-10-35(2)11-9-19/h3-7,12-15,19H,8-11H2,1-2H3,(H,32,36)(H,33,37)(H,30,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM26376 (4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...) Show SMILES CN1CCC(CC1)Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C26H27F3N6O2/c1-16-6-7-20(32-23(36)17-4-3-5-18(12-17)26(27,28)29)13-22(16)24(37)33-21-14-30-25(31-15-21)34-19-8-10-35(2)11-9-19/h3-7,12-15,19H,8-11H2,1-2H3,(H,32,36)(H,33,37)(H,30,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26376 (4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...) Show SMILES CN1CCC(CC1)Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C26H27F3N6O2/c1-16-6-7-20(32-23(36)17-4-3-5-18(12-17)26(27,28)29)13-22(16)24(37)33-21-14-30-25(31-15-21)34-19-8-10-35(2)11-9-19/h3-7,12-15,19H,8-11H2,1-2H3,(H,32,36)(H,33,37)(H,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair