Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM27887 (4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-{6-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Bristol-Myers Squibb Company | Assay Description The IGF-1 receptor tyrosine kinase was assayed using the synthetic polymer poly(Glu/Tyr) as a phosphoacceptor substrate. Incorporated radioactivity w... | J Med Chem 51: 5897-900 (2008) Article DOI: 10.1021/jm800832q BindingDB Entry DOI: 10.7270/Q2513WJK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM27887 (4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-{6-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.95E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bristol-Myers Squibb Company | Assay Description The inhibition of recombinant human CYP3A4 was measured as the ability to perform a dealkylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Befo... | J Med Chem 51: 5897-900 (2008) Article DOI: 10.1021/jm800832q BindingDB Entry DOI: 10.7270/Q2513WJK | |||||||||||
More data for this Ligand-Target Pair |