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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara... | ACS Med Chem Lett 11: 101-107 (2020) Article DOI: 10.1021/acsmedchemlett.9b00509 BindingDB Entry DOI: 10.7270/Q28G8Q0N | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP], mitochondrial (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co... | ACS Med Chem Lett 11: 101-107 (2020) Article DOI: 10.1021/acsmedchemlett.9b00509 BindingDB Entry DOI: 10.7270/Q28G8Q0N | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP], mitochondrial (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ... | ACS Med Chem Lett 11: 101-107 (2020) Article DOI: 10.1021/acsmedchemlett.9b00509 BindingDB Entry DOI: 10.7270/Q28G8Q0N | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Agios Pharmaceuticals, Inc. US Patent | Assay Description A test compound is prepared as 10 mM stock in DMSO and diluted to 50× final concentration in DMSO, for a 50 μl reaction mixture. IDH enzyme acti... | US Patent US10028961 (2018) BindingDB Entry DOI: 10.7270/Q2ZW1NXM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. US Patent | Assay Description In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema... | US Patent US10172864 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JQ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. US Patent | Assay Description In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema... | US Patent US10172864 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JQ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. US Patent | Assay Description Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio... | US Patent US10172864 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JQ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. US Patent | Assay Description A test compound is prepared as 10 mM stock in DMSO and diluted to 50× final concentration in DMSO, for a 50 μl reaction mixture. IDH enzyme acti... | US Patent US10172864 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JQ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. US Patent | Assay Description A test compound is prepared as 10 mM stock in DMSO and diluted to 50× final concentration in DMSO, for a 50 μl reaction mixture. IDH enzyme acti... | US Patent US10946023 (2021) BindingDB Entry DOI: 10.7270/Q2S46W3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. US Patent | Assay Description In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema... | US Patent US10946023 (2021) BindingDB Entry DOI: 10.7270/Q2S46W3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. US Patent | Assay Description In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema... | US Patent US10946023 (2021) BindingDB Entry DOI: 10.7270/Q2S46W3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Agios Pharmaceuticals, Inc. US Patent | Assay Description Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio... | US Patent US10028961 (2018) BindingDB Entry DOI: 10.7270/Q2ZW1NXM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Agios Pharmaceuticals, Inc. US Patent | Assay Description Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio... | US Patent US10946023 (2021) BindingDB Entry DOI: 10.7270/Q2S46W3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | 6.5 | 25 |
Agios Pharmaceuticals, Inc. US Patent | Assay Description In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema... | US Patent US10028961 (2018) BindingDB Entry DOI: 10.7270/Q2ZW1NXM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Homo sapiens (Human)) | BDBM279996 (US10028961, Compound 149 | US10172864, Compound 14...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | 6.5 | 25 |
Agios Pharmaceuticals, Inc. US Patent | Assay Description In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema... | US Patent US10028961 (2018) BindingDB Entry DOI: 10.7270/Q2ZW1NXM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
