BindingDB PrimarySearch

Found 6 hits of ic50 for monomerid = 291688
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human))	BDBM291688 (8-(2,4-Dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-di...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...				US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7
Novartis AG US Patent					More data for this Ligand-Target Pair
Polycomb protein EED (Homo sapiens (Human))	BDBM291688 (8-(2,4-Dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-di...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH
TBA					More data for this Ligand-Target Pair
Polycomb protein EED (Homo sapiens (Human))	BDBM291688 (8-(2,4-Dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-di...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH
TBA					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human))	BDBM291688 (8-(2,4-Dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-di...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	8.0	n/a
Novartis AG US Patent					Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...				US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7
Novartis AG US Patent					More data for this Ligand-Target Pair
Polycomb protein EED (Homo sapiens (Human))	BDBM291688 (8-(2,4-Dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-di...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH
TBA					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human))	BDBM291688 (8-(2,4-Dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-di...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	8.0	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...				US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7
Novartis AG US Patent					More data for this Ligand-Target Pair