BindingDB PrimarySearch

Found 8 hits of ic50 for monomerid = 322528
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
Redx Pharma PLC US Patent					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent					Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...				US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
Redx Pharma PLC US Patent					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718
TBA					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718
TBA					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
Redx Pharma PLC US Patent					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent					Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...				US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
Redx Pharma PLC US Patent					More data for this Ligand-Target Pair