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Compile Data Set for Download or QSAR

Found 2 hits of ic50 for monomerid = 32568   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM32568
PNG
(arylsulfonylpiperazine, 40)
Show SMILES CCC1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C22H28F3N3O2S/c1-5-17-15-27(20-19(22(23,24)25)7-6-12-26-20)13-14-28(17)31(29,30)18-10-8-16(9-11-18)21(2,3)4/h6-12,17H,5,13-15H2,1-4H3
PDB
MMDB

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UniProtKB/SwissProt

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DrugBank
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AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S]


(Homo sapiens (Human))
BDBM32568
PNG
(arylsulfonylpiperazine, 40)
Show SMILES CCC1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C22H28F3N3O2S/c1-5-17-15-27(20-19(22(23,24)25)7-6-12-26-20)13-14-28(17)31(29,30)18-10-8-16(9-11-18)21(2,3)4/h6-12,17H,5,13-15H2,1-4H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/a>1.00E+3n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair