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Compile Data Set for Download or QSAR

Found 2 hits of ic50 for monomerid = 337065   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337065
PNG
(US9745291, Compound 111 | US9765068, Compound 111)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCC(O)C1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O6S/c28-20-10-12-27(16-20)34(31,32)23-8-4-3-7-22(23)33-17-24(30)25-13-21(29)15-26-11-9-18-5-1-2-6-19(18)14-26/h1-8,20-21,28-29H,9-17H2,(H,25,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)


BindingDB Entry DOI: 10.7270/Q2959KN3
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337065
PNG
(US9745291, Compound 111 | US9765068, Compound 111)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCC(O)C1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O6S/c28-20-10-12-27(16-20)34(31,32)23-8-4-3-7-22(23)33-17-24(30)25-13-21(29)15-26-11-9-18-5-1-2-6-19(18)14-26/h1-8,20-21,28-29H,9-17H2,(H,25,30)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9745291 (2017)


BindingDB Entry DOI: 10.7270/Q2J1058K
More data for this
Ligand-Target Pair