Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Competitive reversible inhibition of DPP4 (unknown origin) | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent | Assay Description Screening Method:Name of method: Activity Evaluation of DPP4, Fluorescence.Instrument: Microplate reader, Envision (PerkinElmer, USA).Material: human... | US Patent US10479798 (2019) BindingDB Entry DOI: 10.7270/Q2377C4Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of DPP4 (unknown origin) expressed in Sf9 cells using Gly-Pro-AMC substrate | J Med Chem 59: 6772-90 (2016) Article DOI: 10.1021/acs.jmedchem.6b00505 BindingDB Entry DOI: 10.7270/Q2DV1MWF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Haisco Pharmaceutical Group Company Ltd. Curated by ChEMBL | Assay Description Inhibition of human recombinant DPP4 incubated for 15 mins using Gly-Pro-7-AMC substrate | J Med Chem 63: 7108-7126 (2020) Article DOI: 10.1021/acs.jmedchem.0c00374 BindingDB Entry DOI: 10.7270/Q2R214X8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Rattus norvegicus (rat)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.; CENTAURUS BIOPHARMA CO., LTD. US Patent | Assay Description a. White 384-well plate (Perkin Elmer, Catalog No. 607290/99)b. HEPES buffer: using 1M HEPES buffer (Invitrogen, Catalog No. 15630-080) to prepare 50... | US Patent US10822319 (2020) BindingDB Entry DOI: 10.7270/Q2028VN6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd. US Patent | Assay Description 1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou... | US Patent US10155775 (2018) BindingDB Entry DOI: 10.7270/Q2NK3H32 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Mus musculus) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of DPP4 in mouse plasma | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of Cav1.2 (unknown origin) | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of human ERG by MK-499 displacement binding analysis | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of Nav1.5 (unknown origin) | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 9 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of DPP9 (unknown origin) | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 8 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of DPP8 (unknown origin) | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of PEP (unknown origin) | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase FAP (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of FAP (unknown origin) | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 2 (Homo sapiens (Human)) | BDBM50003020 (MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of QPP (unknown origin) | J Med Chem 57: 3205-12 (2014) Article DOI: 10.1021/jm401992e BindingDB Entry DOI: 10.7270/Q2WD423H | |||||||||||
More data for this Ligand-Target Pair |