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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N-methyl-D-aspartate receptor (Sus scrofa) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Zentrum für Pharmaforschung Curated by ChEMBL | Assay Description Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of por... | Bioorg Med Chem Lett 10: 1377-80 (2000) BindingDB Entry DOI: 10.7270/Q2Q52NVP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| N-methyl-D-aspartate receptor (Sus scrofa) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 277 | n/a | n/a | n/a | n/a | n/a | n/a |
Zentrum für Pharmaforschung Curated by ChEMBL | Assay Description Displacement of [3H]-ifendropil from binding site of N-methyl-D-aspartate glutamate receptor was evaluated employing synaptosomal fraction of porcine... | Bioorg Med Chem Lett 10: 1377-80 (2000) BindingDB Entry DOI: 10.7270/Q2Q52NVP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for the Alpha-1 adrenergic receptor affinity in a standard radioligand binding assay with [3H]- prazosin | Bioorg Med Chem Lett 3: 91-94 (1993) Article DOI: 10.1016/S0960-894X(00)80098-0 BindingDB Entry DOI: 10.7270/Q2GT5N4S | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul... | Bioorg Med Chem Lett 3: 91-94 (1993) Article DOI: 10.1016/S0960-894X(00)80098-0 BindingDB Entry DOI: 10.7270/Q2GT5N4S | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutamate receptor ionotropic, NMDA 1/2B (Rattus norvegicus (Rat)-RAT) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes | J Med Chem 42: 2993-3000 (1999) Article DOI: 10.1021/jm990246i BindingDB Entry DOI: 10.7270/Q2RX9B8W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| N-methyl-D-aspartate receptor (Sus scrofa) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Zentrum für Pharmaforschung Curated by ChEMBL | Assay Description Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor lacking NR2B subunit in low affinity fraction of... | Bioorg Med Chem Lett 10: 1377-80 (2000) BindingDB Entry DOI: 10.7270/Q2Q52NVP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutamate receptor ionotropic, NMDA 1/2C (RAT-Rattus norvegicus (Rat)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory concentration against NMDA responses at NR1A/2C receptors expressed in Xenopus oocytes | J Med Chem 42: 2993-3000 (1999) Article DOI: 10.1021/jm990246i BindingDB Entry DOI: 10.7270/Q2RX9B8W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory concentration against NMDA responses at cloned NR1A/2A receptors expressed in Xenopus oocytes | J Med Chem 42: 2993-3000 (1999) Article DOI: 10.1021/jm990246i BindingDB Entry DOI: 10.7270/Q2RX9B8W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
