Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrin alpha-L/beta-2 (Homo sapiens (Human)) | BDBM50092956 (1-(4-Acetyl-piperazin-1-yl)-3-[4-(2-isopropyl-phen...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(12-60) | J Med Chem 44: 4393-403 (2001) BindingDB Entry DOI: 10.7270/Q2WW7GZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Intercellular adhesion molecule 1 (Homo sapiens (Human)) | BDBM50092956 (1-(4-Acetyl-piperazin-1-yl)-3-[4-(2-isopropyl-phen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Evaluated for its ability to block the adherence of JY-8 cells to immobilized ICAM-1. | J Med Chem 43: 4025-40 (2000) BindingDB Entry DOI: 10.7270/Q22Z14S7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin beta-2/Intercellular adhesion molecule 1 (Homo sapiens (Human)) | BDBM50092956 (1-(4-Acetyl-piperazin-1-yl)-3-[4-(2-isopropyl-phen...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunesis Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assay | Bioorg Med Chem Lett 20: 5269-73 (2010) Article DOI: 10.1016/j.bmcl.2010.06.145 BindingDB Entry DOI: 10.7270/Q2N58MKB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-L (Homo sapiens (Human)) | BDBM50092956 (1-(4-Acetyl-piperazin-1-yl)-3-[4-(2-isopropyl-phen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of intercellular adhesion molecule-1 (ICAM-1) binding to recombinant LFA-1, range(30-60) | J Med Chem 44: 4393-403 (2001) BindingDB Entry DOI: 10.7270/Q2WW7GZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-L/beta-2 (Homo sapiens (Human)) | BDBM50092956 (1-(4-Acetyl-piperazin-1-yl)-3-[4-(2-isopropyl-phen...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of JY-8 cell adhesion via leukocyte function associated antigen 1 (LFA-1) to ICAM-1 | J Med Chem 44: 1202-10 (2001) BindingDB Entry DOI: 10.7270/Q22Z14TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1 (Homo sapiens (Human)) | BDBM50092956 (1-(4-Acetyl-piperazin-1-yl)-3-[4-(2-isopropyl-phen...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical inter... | J Med Chem 43: 4025-40 (2000) BindingDB Entry DOI: 10.7270/Q22Z14S7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1 (Homo sapiens (Human)) | BDBM50092956 (1-(4-Acetyl-piperazin-1-yl)-3-[4-(2-isopropyl-phen...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Ability to antagonise the Leukocyte function-associated Antigen-1/ Intracellular Adhesion molecule-1 interaction (LFA-1/ICAM-1) | J Med Chem 44: 2913-20 (2001) BindingDB Entry DOI: 10.7270/Q2PZ5831 | |||||||||||
More data for this Ligand-Target Pair |