Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50152067 (CHEMBL3781397) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu University Curated by ChEMBL | Assay Description Inhibition of recombinant GST-tagged human SIRT1 using 0.3 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC anal... | Bioorg Med Chem Lett 26: 1612-7 (2016) Article DOI: 10.1016/j.bmcl.2016.01.086 BindingDB Entry DOI: 10.7270/Q2HM5B9J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human)) | BDBM50152067 (CHEMBL3781397) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu University Curated by ChEMBL | Assay Description Inhibition of recombinant His6 tagged human SIRT3 using 0.105 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC a... | Bioorg Med Chem Lett 26: 1612-7 (2016) Article DOI: 10.1016/j.bmcl.2016.01.086 BindingDB Entry DOI: 10.7270/Q2HM5B9J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human)) | BDBM50152067 (CHEMBL3781397) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 144 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu University Curated by ChEMBL | Assay Description Inhibition of recombinant His6 tagged human SIRT2 using 0.39 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 12 mins HPLC an... | Bioorg Med Chem Lett 26: 1612-7 (2016) Article DOI: 10.1016/j.bmcl.2016.01.086 BindingDB Entry DOI: 10.7270/Q2HM5B9J | |||||||||||
More data for this Ligand-Target Pair |