Found 4 hits of ic50 for monomerid = 50153166 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153166
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50153166
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase |
Bioorg Med Chem Lett 14: 5057-62 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153166
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50153166
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 14: 5057-62 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C |
More data for this
Ligand-Target Pair | |
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