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Compile Data Set for Download or QSAR

Found 4 hits of ic50 for monomerid = 50177833   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50177833
PNG
(2-(2,2-Difluoroethoxy)-5-{[6-methoxy-7-(2-methoxye...)
Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCC(F)F)=CC3=O)c2cc1OC |w:12.11,c:22|
Show InChI InChI=1S/C20H19F2N3O6/c1-28-3-4-30-18-7-12-11(5-17(18)29-2)20(24-10-23-12)25-13-6-15(27)16(8-14(13)26)31-9-19(21)22/h5,7-8,10,19H,3-4,6,9H2,1-2H3
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PubMed
n/an/a 4.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP


J Med Chem 48: 7560-81 (2005)


Article DOI: 10.1021/jm050559f
BindingDB Entry DOI: 10.7270/Q2028R3S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50177833
PNG
(2-(2,2-Difluoroethoxy)-5-{[6-methoxy-7-(2-methoxye...)
Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCC(F)F)=CC3=O)c2cc1OC |w:12.11,c:22|
Show InChI InChI=1S/C20H19F2N3O6/c1-28-3-4-30-18-7-12-11(5-17(18)29-2)20(24-10-23-12)25-13-6-15(27)16(8-14(13)26)31-9-19(21)22/h5,7-8,10,19H,3-4,6,9H2,1-2H3
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Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma


J Med Chem 48: 7560-81 (2005)


Article DOI: 10.1021/jm050559f
BindingDB Entry DOI: 10.7270/Q2028R3S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50177833
PNG
(2-(2,2-Difluoroethoxy)-5-{[6-methoxy-7-(2-methoxye...)
Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCC(F)F)=CC3=O)c2cc1OC |w:12.11,c:22|
Show InChI InChI=1S/C20H19F2N3O6/c1-28-3-4-30-18-7-12-11(5-17(18)29-2)20(24-10-23-12)25-13-6-15(27)16(8-14(13)26)31-9-19(21)22/h5,7-8,10,19H,3-4,6,9H2,1-2H3
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Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma


J Med Chem 48: 7560-81 (2005)


Article DOI: 10.1021/jm050559f
BindingDB Entry DOI: 10.7270/Q2028R3S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50177833
PNG
(2-(2,2-Difluoroethoxy)-5-{[6-methoxy-7-(2-methoxye...)
Show SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(OCC(F)F)=CC3=O)c2cc1OC |w:12.11,c:22|
Show InChI InChI=1S/C20H19F2N3O6/c1-28-3-4-30-18-7-12-11(5-17(18)29-2)20(24-10-23-12)25-13-6-15(27)16(8-14(13)26)31-9-19(21)22/h5,7-8,10,19H,3-4,6,9H2,1-2H3
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 870n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells


J Med Chem 48: 7560-81 (2005)


Article DOI: 10.1021/jm050559f
BindingDB Entry DOI: 10.7270/Q2028R3S
More data for this
Ligand-Target Pair