Found 3 hits of ic50 for monomerid = 50232453 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50232453
(CHEMBL4091906 | US10214537, Example 271)Show SMILES C[C@H]1CN(C[C@@H](C)N1c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12)C(=O)C(C)(C)O |r| Show InChI InChI=1S/C30H38N8O3/c1-19-16-35(29(39)30(3,4)40)17-20(2)36(19)23-7-5-6-21(14-23)26-15-24(27-28(31)32-18-34-38(26)27)25-8-11-33-37(25)22-9-12-41-13-10-22/h5-8,11,14-15,18-20,22,40H,9-10,12-13,16-17H2,1-4H3,(H2,31,32,34)/t19-,20+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assay |
Bioorg Med Chem Lett 27: 855-861 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.016 BindingDB Entry DOI: 10.7270/Q2BR8VFH |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50232453
(CHEMBL4091906 | US10214537, Example 271)Show SMILES C[C@H]1CN(C[C@@H](C)N1c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12)C(=O)C(C)(C)O |r| Show InChI InChI=1S/C30H38N8O3/c1-19-16-35(29(39)30(3,4)40)17-20(2)36(19)23-7-5-6-21(14-23)26-15-24(27-28(31)32-18-34-38(26)27)25-8-11-33-37(25)22-9-12-41-13-10-22/h5-8,11,14-15,18-20,22,40H,9-10,12-13,16-17H2,1-4H3,(H2,31,32,34)/t19-,20+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr... |
US Patent US10214537 (2019)
BindingDB Entry DOI: 10.7270/Q2HH6NB2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50232453
(CHEMBL4091906 | US10214537, Example 271)Show SMILES C[C@H]1CN(C[C@@H](C)N1c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12)C(=O)C(C)(C)O |r| Show InChI InChI=1S/C30H38N8O3/c1-19-16-35(29(39)30(3,4)40)17-20(2)36(19)23-7-5-6-21(14-23)26-15-24(27-28(31)32-18-34-38(26)27)25-8-11-33-37(25)22-9-12-41-13-10-22/h5-8,11,14-15,18-20,22,40H,9-10,12-13,16-17H2,1-4H3,(H2,31,32,34)/t19-,20+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 291 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta in human whole blood assessed as suppression of CD69 expression incubated for 60 mins |
Bioorg Med Chem Lett 27: 855-861 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.016 BindingDB Entry DOI: 10.7270/Q2BR8VFH |
More data for this Ligand-Target Pair | |