Found 4 hits of ic50 for monomerid = 50234145 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234145
(CHEMBL4096090)Show SMILES Cn1nc(nc1Cc1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H17N9/c1-28-17(11-13-7-3-2-4-8-13)24-19(26-28)15-12-22-18(21)20(23-15)29-16-10-6-5-9-14(16)25-27-29/h2-10,12H,11H2,1H3,(H2,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004 BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234145
(CHEMBL4096090)Show SMILES Cn1nc(nc1Cc1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H17N9/c1-28-17(11-13-7-3-2-4-8-13)24-19(26-28)15-12-22-18(21)20(23-15)29-16-10-6-5-9-14(16)25-27-29/h2-10,12H,11H2,1H3,(H2,21,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004 BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234145
(CHEMBL4096090)Show SMILES Cn1nc(nc1Cc1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H17N9/c1-28-17(11-13-7-3-2-4-8-13)24-19(26-28)15-12-22-18(21)20(23-15)29-16-10-6-5-9-14(16)25-27-29/h2-10,12H,11H2,1H3,(H2,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004 BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234145
(CHEMBL4096090)Show SMILES Cn1nc(nc1Cc1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H17N9/c1-28-17(11-13-7-3-2-4-8-13)24-19(26-28)15-12-22-18(21)20(23-15)29-16-10-6-5-9-14(16)25-27-29/h2-10,12H,11H2,1H3,(H2,21,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004 BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this Ligand-Target Pair | |