Found 2 hits of ic50 for monomerid = 50237492 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50237492
(CHEMBL4065188)Show SMILES N[C@H]1CC[C@](CCOc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)(CC1)c1ccc(Cl)cc1 |r,wU:1.0,wD:4.4,(6.2,-22.18,;6.25,-20.64,;4.94,-19.82,;4.99,-18.29,;6.34,-17.57,;7.12,-16.25,;8.66,-16.25,;9.42,-17.59,;10.96,-17.6,;11.72,-16.28,;13.26,-16.28,;14.03,-14.95,;14.03,-17.62,;13.25,-18.95,;11.71,-18.94,;10.93,-20.27,;15.57,-17.62,;15.98,-16.13,;17.06,-17.23,;16.33,-18.96,;17.87,-18.97,;18.78,-17.73,;20.24,-18.21,;20.23,-19.74,;18.77,-20.21,;7.66,-18.37,;7.61,-19.91,;5.24,-16.47,;5.65,-14.97,;4.56,-13.87,;3.05,-14.27,;1.96,-13.18,;2.65,-15.78,;3.75,-16.88,)| Show InChI InChI=1S/C22H23ClF2N4O3S2/c23-15-3-1-14(2-4-15)22(7-5-16(26)6-8-22)9-10-32-19-11-18(25)20(12-17(19)24)34(30,31)29-21-27-13-28-33-21/h1-4,11-13,16H,5-10,26H2,(H,27,28,29)/t16-,22+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 388 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -60 mV holding potential measured af... |
J Med Chem 60: 2513-2525 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01918 BindingDB Entry DOI: 10.7270/Q2057J69 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50237492
(CHEMBL4065188)Show SMILES N[C@H]1CC[C@](CCOc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)(CC1)c1ccc(Cl)cc1 |r,wU:1.0,wD:4.4,(6.2,-22.18,;6.25,-20.64,;4.94,-19.82,;4.99,-18.29,;6.34,-17.57,;7.12,-16.25,;8.66,-16.25,;9.42,-17.59,;10.96,-17.6,;11.72,-16.28,;13.26,-16.28,;14.03,-14.95,;14.03,-17.62,;13.25,-18.95,;11.71,-18.94,;10.93,-20.27,;15.57,-17.62,;15.98,-16.13,;17.06,-17.23,;16.33,-18.96,;17.87,-18.97,;18.78,-17.73,;20.24,-18.21,;20.23,-19.74,;18.77,-20.21,;7.66,-18.37,;7.61,-19.91,;5.24,-16.47,;5.65,-14.97,;4.56,-13.87,;3.05,-14.27,;1.96,-13.18,;2.65,-15.78,;3.75,-16.88,)| Show InChI InChI=1S/C22H23ClF2N4O3S2/c23-15-3-1-14(2-4-15)22(7-5-16(26)6-8-22)9-10-32-19-11-18(25)20(12-17(19)24)34(30,31)29-21-27-13-28-33-21/h1-4,11-13,16H,5-10,26H2,(H,27,28,29)/t16-,22+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Nav1.5 expressed in HEK293 cells assessed as reduction in peak inward current at -50 mV holding potential measured af... |
J Med Chem 60: 2513-2525 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01918 BindingDB Entry DOI: 10.7270/Q2057J69 |
More data for this Ligand-Target Pair | |