Found 2 hits of ic50 for monomerid = 50265849 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50265849
(2-(dimethylamino)-1-(7-(4-(indolin-1-yl)-7H-pyrrol...)Show SMILES COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(N2CCc3ccccc23)c2cc[nH]c2n1 Show InChI InChI=1S/C28H31N7O2/c1-33(2)17-25(36)34-13-6-8-19-15-24(37-3)21(16-23(19)34)30-28-31-26-20(10-12-29-26)27(32-28)35-14-11-18-7-4-5-9-22(18)35/h4-5,7,9-10,12,15-16H,6,8,11,13-14,17H2,1-3H3,(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 19: 373-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50265849
(2-(dimethylamino)-1-(7-(4-(indolin-1-yl)-7H-pyrrol...)Show SMILES COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(N2CCc3ccccc23)c2cc[nH]c2n1 Show InChI InChI=1S/C28H31N7O2/c1-33(2)17-25(36)34-13-6-8-19-15-24(37-3)21(16-23(19)34)30-28-31-26-20(10-12-29-26)27(32-28)35-14-11-18-7-4-5-9-22(18)35/h4-5,7,9-10,12,15-16H,6,8,11,13-14,17H2,1-3H3,(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of IGF1R phosphorylation by cellular assay |
Bioorg Med Chem Lett 19: 373-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC |
More data for this Ligand-Target Pair | |