Found 2 hits of ic50 for monomerid = 50297796 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50297796
(4-(cyclohexylmethyl)-6-(2-methoxypyrimidin-5-yl)-2...)Show SMILES COc1ncc(cn1)-c1ccc2nc(NCC3CCOCC3)c(=O)n(CC3CCCCC3)c2n1 Show InChI InChI=1S/C25H32N6O3/c1-33-25-27-14-19(15-28-25)20-7-8-21-23(30-20)31(16-18-5-3-2-4-6-18)24(32)22(29-21)26-13-17-9-11-34-12-10-17/h7-8,14-15,17-18H,2-6,9-13,16H2,1H3,(H,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of PDE5 |
Bioorg Med Chem Lett 19: 4088-91 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.012 BindingDB Entry DOI: 10.7270/Q23R0SXR |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50297796
(4-(cyclohexylmethyl)-6-(2-methoxypyrimidin-5-yl)-2...)Show SMILES COc1ncc(cn1)-c1ccc2nc(NCC3CCOCC3)c(=O)n(CC3CCCCC3)c2n1 Show InChI InChI=1S/C25H32N6O3/c1-33-25-27-14-19(15-28-25)20-7-8-21-23(30-20)31(16-18-5-3-2-4-6-18)24(32)22(29-21)26-13-17-9-11-34-12-10-17/h7-8,14-15,17-18H,2-6,9-13,16H2,1H3,(H,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 0.302 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of PDE5 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-010-9523-y BindingDB Entry DOI: 10.7270/Q2JW8HS3 |
More data for this Ligand-Target Pair | |