Search and Browse
Download
Enter Data
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach | Citation and Details | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universität Dortmund | Assay Description IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A... | ACS Chem Biol 10: 279-88 (2015) Article DOI: 10.1021/cb500355c BindingDB Entry DOI: 10.7270/Q218358G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TECHNISCHE UNIVERSITÄT DORTMUND US Patent | Assay Description iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A... | US Patent US10550114 (2020) BindingDB Entry DOI: 10.7270/Q2DV1N97 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TECHNISCHE UNIVERSITÄT DORTMUND US Patent | Assay Description iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A... | US Patent US10550114 (2020) BindingDB Entry DOI: 10.7270/Q2DV1N97 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01467 BindingDB Entry DOI: 10.7270/Q24Q801K | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Curated by ChEMBL | Assay Description Inhibition of Akt1 | J Med Chem 53: 1413-37 (2010) Article DOI: 10.1021/jm901132v BindingDB Entry DOI: 10.7270/Q2VD6ZK0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibition of choline acetyltransferase (ChAT) activity | Citation and Details | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Curated by ChEMBL | Assay Description Inhibition of Akt2 | J Med Chem 53: 1413-37 (2010) Article DOI: 10.1021/jm901132v BindingDB Entry DOI: 10.7270/Q2VD6ZK0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach | Citation and Details | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibition of acetylcholinesterase (AChE) activity | Citation and Details | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibition of choline acetyltransferase (ChAT) activity | Citation and Details | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Curated by ChEMBL | Assay Description Inhibition of Akt3 | J Med Chem 53: 1413-37 (2010) Article DOI: 10.1021/jm901132v BindingDB Entry DOI: 10.7270/Q2VD6ZK0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum | Citation and Details | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAC-alpha serine/threonine-protein kinase [E17K] (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 3.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TECHNISCHE UNIVERSITÄT DORTMUND US Patent | Assay Description iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A... | US Patent US10550114 (2020) BindingDB Entry DOI: 10.7270/Q2DV1N97 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
