BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits of ic50 for monomerid = 50343192   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50343192
PNG
(CHEMBL1773579 | N-(6-(2-(3-Fluorophenylsulfonamido...)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NS(=O)(=O)c2cccc(F)c2)n1
Show InChI InChI=1S/C19H14FN5O3S2/c1-11(26)22-19-24-16-6-5-12(9-17(16)29-19)15-7-8-21-18(23-15)25-30(27,28)14-4-2-3-13(20)10-14/h2-10H,1H3,(H,21,23,25)(H,22,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50343192
PNG
(CHEMBL1773579 | N-(6-(2-(3-Fluorophenylsulfonamido...)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NS(=O)(=O)c2cccc(F)c2)n1
Show InChI InChI=1S/C19H14FN5O3S2/c1-11(26)22-19-24-16-6-5-12(9-17(16)29-19)15-7-8-21-18(23-15)25-30(27,28)14-4-2-3-13(20)10-14/h2-10H,1H3,(H,21,23,25)(H,22,24,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrs


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair