Found 4 hits of ic50 for monomerid = 50354408 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein-tyrosine kinase 6
(Homo sapiens (Human)) | BDBM50354408
(CHEMBL1836867)Show SMILES Cc1cn2c(cnc2c(Nc2ccc(C(=O)N3CCNCC3)c(Cl)c2)n1)-c1cn[nH]c1 Show InChI InChI=1S/C21H21ClN8O/c1-13-12-30-18(14-9-25-26-10-14)11-24-20(30)19(27-13)28-15-2-3-16(17(22)8-15)21(31)29-6-4-23-5-7-29/h2-3,8-12,23H,4-7H2,1H3,(H,25,26)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of BRK pretreated for 30 mins by microplate reader |
Bioorg Med Chem Lett 21: 5870-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.101
BindingDB Entry DOI: 10.7270/Q2PR7WCR |
More data for this
Ligand-Target Pair | |
Protein-tyrosine kinase 6
(Homo sapiens (Human)) | BDBM50354408
(CHEMBL1836867)Show SMILES Cc1cn2c(cnc2c(Nc2ccc(C(=O)N3CCNCC3)c(Cl)c2)n1)-c1cn[nH]c1 Show InChI InChI=1S/C21H21ClN8O/c1-13-12-30-18(14-9-25-26-10-14)11-24-20(30)19(27-13)28-15-2-3-16(17(22)8-15)21(31)29-6-4-23-5-7-29/h2-3,8-12,23H,4-7H2,1H3,(H,25,26)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylated SAM68 in 293 WT-PTK6 cells after 3 hrs |
Bioorg Med Chem Lett 21: 5870-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.101
BindingDB Entry DOI: 10.7270/Q2PR7WCR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50354408
(CHEMBL1836867)Show SMILES Cc1cn2c(cnc2c(Nc2ccc(C(=O)N3CCNCC3)c(Cl)c2)n1)-c1cn[nH]c1 Show InChI InChI=1S/C21H21ClN8O/c1-13-12-30-18(14-9-25-26-10-14)11-24-20(30)19(27-13)28-15-2-3-16(17(22)8-15)21(31)29-6-4-23-5-7-29/h2-3,8-12,23H,4-7H2,1H3,(H,25,26)(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of LCK |
Bioorg Med Chem Lett 21: 5870-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.101
BindingDB Entry DOI: 10.7270/Q2PR7WCR |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50354408
(CHEMBL1836867)Show SMILES Cc1cn2c(cnc2c(Nc2ccc(C(=O)N3CCNCC3)c(Cl)c2)n1)-c1cn[nH]c1 Show InChI InChI=1S/C21H21ClN8O/c1-13-12-30-18(14-9-25-26-10-14)11-24-20(30)19(27-13)28-15-2-3-16(17(22)8-15)21(31)29-6-4-23-5-7-29/h2-3,8-12,23H,4-7H2,1H3,(H,25,26)(H,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 754 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of AurB |
Bioorg Med Chem Lett 21: 5870-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.101
BindingDB Entry DOI: 10.7270/Q2PR7WCR |
More data for this
Ligand-Target Pair | |
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