Found 4 hits of ic50 for monomerid = 50354429 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein-tyrosine kinase 6
(Homo sapiens (Human)) | BDBM50354429
(CHEMBL1836846)Show SMILES Clc1cc(Nc2nc(cn3c(cnc23)-c2cn[nH]c2)C2CC2)ccc1C(=O)N1C[C@H]2CC[C@@H]1CN2 |r| Show InChI InChI=1S/C25H25ClN8O/c26-20-7-16(4-6-19(20)25(35)33-12-17-3-5-18(33)10-27-17)31-23-24-28-11-22(15-8-29-30-9-15)34(24)13-21(32-23)14-1-2-14/h4,6-9,11,13-14,17-18,27H,1-3,5,10,12H2,(H,29,30)(H,31,32)/t17-,18-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of BRK pretreated for 30 mins by microplate reader |
Bioorg Med Chem Lett 21: 5870-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.101 BindingDB Entry DOI: 10.7270/Q2PR7WCR |
More data for this Ligand-Target Pair | |
Protein-tyrosine kinase 6
(Homo sapiens (Human)) | BDBM50354429
(CHEMBL1836846)Show SMILES Clc1cc(Nc2nc(cn3c(cnc23)-c2cn[nH]c2)C2CC2)ccc1C(=O)N1C[C@H]2CC[C@@H]1CN2 |r| Show InChI InChI=1S/C25H25ClN8O/c26-20-7-16(4-6-19(20)25(35)33-12-17-3-5-18(33)10-27-17)31-23-24-28-11-22(15-8-29-30-9-15)34(24)13-21(32-23)14-1-2-14/h4,6-9,11,13-14,17-18,27H,1-3,5,10,12H2,(H,29,30)(H,31,32)/t17-,18-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of phosphorylated SAM68 in 293 WT-PTK6 cells after 3 hrs |
Bioorg Med Chem Lett 21: 5870-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.101 BindingDB Entry DOI: 10.7270/Q2PR7WCR |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50354429
(CHEMBL1836846)Show SMILES Clc1cc(Nc2nc(cn3c(cnc23)-c2cn[nH]c2)C2CC2)ccc1C(=O)N1C[C@H]2CC[C@@H]1CN2 |r| Show InChI InChI=1S/C25H25ClN8O/c26-20-7-16(4-6-19(20)25(35)33-12-17-3-5-18(33)10-27-17)31-23-24-28-11-22(15-8-29-30-9-15)34(24)13-21(32-23)14-1-2-14/h4,6-9,11,13-14,17-18,27H,1-3,5,10,12H2,(H,29,30)(H,31,32)/t17-,18-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of LCK |
Bioorg Med Chem Lett 21: 5870-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.101 BindingDB Entry DOI: 10.7270/Q2PR7WCR |
More data for this Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50354429
(CHEMBL1836846)Show SMILES Clc1cc(Nc2nc(cn3c(cnc23)-c2cn[nH]c2)C2CC2)ccc1C(=O)N1C[C@H]2CC[C@@H]1CN2 |r| Show InChI InChI=1S/C25H25ClN8O/c26-20-7-16(4-6-19(20)25(35)33-12-17-3-5-18(33)10-27-17)31-23-24-28-11-22(15-8-29-30-9-15)34(24)13-21(32-23)14-1-2-14/h4,6-9,11,13-14,17-18,27H,1-3,5,10,12H2,(H,29,30)(H,31,32)/t17-,18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of AurB |
Bioorg Med Chem Lett 21: 5870-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.101 BindingDB Entry DOI: 10.7270/Q2PR7WCR |
More data for this Ligand-Target Pair | |