Compile Data Set for Download or QSAR

Found 6 hits of ic50 for monomerid = 50432658   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50432658 (CHEMBL2347399 | US11407721, Example 2) Show SMILES CN1[C@@H]([C@@H](O[C@@H](Cc2ccccc2)C1=O)c1ccc(Br)cc1)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C24H21Br2NO2/c1-27-22(17-7-11-19(25)12-8-17)23(18-9-13-20(26)14-10-18)29-21(24(27)28)15-16-5-3-2-4-6-16/h2-14,21-23H,15H2,1H3/t21-,22+,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...				J Med Chem 56: 4053-70 (2013) Article DOI: 10.1021/jm400293z BindingDB Entry DOI: 10.7270/Q2HD7X1P
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50432658 (CHEMBL2347399 | US11407721, Example 2) Show SMILES CN1[C@@H]([C@@H](O[C@@H](Cc2ccccc2)C1=O)c1ccc(Br)cc1)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C24H21Br2NO2/c1-27-22(17-7-11-19(25)12-8-17)23(18-9-13-20(26)14-10-18)29-21(24(27)28)15-16-5-3-2-4-6-16/h2-14,21-23H,15H2,1H3/t21-,22+,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...				J Med Chem 56: 4053-70 (2013) Article DOI: 10.1021/jm400293z BindingDB Entry DOI: 10.7270/Q2HD7X1P
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM50432658 (CHEMBL2347399 | US11407721, Example 2) Show SMILES CN1[C@@H]([C@@H](O[C@@H](Cc2ccccc2)C1=O)c1ccc(Br)cc1)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C24H21Br2NO2/c1-27-22(17-7-11-19(25)12-8-17)23(18-9-13-20(26)14-10-18)29-21(24(27)28)15-16-5-3-2-4-6-16/h2-14,21-23H,15H2,1H3/t21-,22+,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				Citation and Details BindingDB Entry DOI: 10.7270/Q20P1378
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM50432658 (CHEMBL2347399 | US11407721, Example 2) Show SMILES CN1[C@@H]([C@@H](O[C@@H](Cc2ccccc2)C1=O)c1ccc(Br)cc1)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C24H21Br2NO2/c1-27-22(17-7-11-19(25)12-8-17)23(18-9-13-20(26)14-10-18)29-21(24(27)28)15-16-5-3-2-4-6-16/h2-14,21-23H,15H2,1H3/t21-,22+,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	4.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...				Citation and Details BindingDB Entry DOI: 10.7270/Q20P1378
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM50432658 (CHEMBL2347399 | US11407721, Example 2) Show SMILES CN1[C@@H]([C@@H](O[C@@H](Cc2ccccc2)C1=O)c1ccc(Br)cc1)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C24H21Br2NO2/c1-27-22(17-7-11-19(25)12-8-17)23(18-9-13-20(26)14-10-18)29-21(24(27)28)15-16-5-3-2-4-6-16/h2-14,21-23H,15H2,1H3/t21-,22+,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	6.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.				Citation and Details BindingDB Entry DOI: 10.7270/Q20P1378
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50432658 (CHEMBL2347399 | US11407721, Example 2) Show SMILES CN1[C@@H]([C@@H](O[C@@H](Cc2ccccc2)C1=O)c1ccc(Br)cc1)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C24H21Br2NO2/c1-27-22(17-7-11-19(25)12-8-17)23(18-9-13-20(26)14-10-18)29-21(24(27)28)15-16-5-3-2-4-6-16/h2-14,21-23H,15H2,1H3/t21-,22+,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...				J Med Chem 56: 4053-70 (2013) Article DOI: 10.1021/jm400293z BindingDB Entry DOI: 10.7270/Q2HD7X1P
					More data for this Ligand-Target Pair				3D Structure (crystal)