Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM116316 (US8637526, 277) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.900 | -51.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Genentech, Inc. US Patent | Assay Description To determine the inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 kinase reactions containing 0.2 nM purified JAK2 ... | US Patent US8637526 (2014) BindingDB Entry DOI: 10.7270/Q25719Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM116316 (US8637526, 277) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 17.6 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
Genentech, Inc. US Patent | Assay Description To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu... | US Patent US8637526 (2014) BindingDB Entry DOI: 10.7270/Q25719Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM116316 (US8637526, 277) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 25.4 | -42.9 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Genentech, Inc. US Patent | Assay Description To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 5 nM purified JAK3 enz... | US Patent US8637526 (2014) BindingDB Entry DOI: 10.7270/Q25719Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM116316 (US8637526, 277) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 43.5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
Genentech, Inc. US Patent | Assay Description To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu... | US Patent US8637526 (2014) BindingDB Entry DOI: 10.7270/Q25719Q3 | |||||||||||
More data for this Ligand-Target Pair |