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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194794 (US9206167, 15 | USRE48059, Compound of Example 15) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194794 (US9206167, 15 | USRE48059, Compound of Example 15) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.200 | -55.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM194794 (US9206167, 15 | USRE48059, Compound of Example 15) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description 5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM194794 (US9206167, 15 | USRE48059, Compound of Example 15) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.30 | -50.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Leysen J E et al. (Leysen J E, Niemegeers C J E, Van Nueten J M and Laduron P M. [3H] Ketanserin (... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
