Found 8 hits of ki for monomerid = 23620 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Equilibrative nucleoside transporter 1
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.18 | -45.7 | 145 | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center
| Assay Description The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i... |
J Med Chem 50: 3906-20 (2007)
Article DOI: 10.1021/jm070311l BindingDB Entry DOI: 10.7270/Q2XK8CVN |
More data for this Ligand-Target Pair | |
Equilibrative nucleoside transporter 1
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee Health Sciences Center
Curated by ChEMBL
| Assay Description Displacement of 5-(SAENTA)-X8-fluorescein from K562 cell nucleoside transporter |
Bioorg Med Chem Lett 14: 2257-60 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.016 BindingDB Entry DOI: 10.7270/Q2NK3FKH |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 87.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Dental College
Curated by PDSP Ki Database
| |
Biochem Pharmacol 55: 209-14 (1998)
Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ |
More data for this Ligand-Target Pair | |
O43924/P16499/P18545/P35913/P51160/Q13956
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 6 |
J Med Chem 48: 3449-62 (2005)
Article DOI: 10.1021/jm040217u BindingDB Entry DOI: 10.7270/Q21G0N2H |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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| Article PubMed
| 162 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Dental College
Curated by PDSP Ki Database
| |
Biochem Pharmacol 55: 209-14 (1998)
Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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| Article PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 11 |
J Med Chem 48: 3449-62 (2005)
Article DOI: 10.1021/jm040217u BindingDB Entry DOI: 10.7270/Q21G0N2H |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 7 |
J Med Chem 48: 3449-62 (2005)
Article DOI: 10.1021/jm040217u BindingDB Entry DOI: 10.7270/Q21G0N2H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description Inhibitory activity against phosphodiesterase 10 |
J Med Chem 48: 3449-62 (2005)
Article DOI: 10.1021/jm040217u BindingDB Entry DOI: 10.7270/Q21G0N2H |
More data for this Ligand-Target Pair | |