Found 12 hits of ki for monomerid = 50062599 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| PDB
Article
PubMed
| 433 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z
BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| PDB
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PubMed
| 690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z
BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2C
(Rattus norvegicus (Rat)) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| Article
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| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Compound with the N-methyl-D-aspartate glutamate receptor blocking activity |
J Med Chem 42: 1481-500 (1999)
Article DOI: 10.1021/jm9805034
BindingDB Entry DOI: 10.7270/Q2HX1DCV |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| PDB
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PubMed
| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z
BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Ionotropic glutamate receptor subunit Delta2
(Xenopus) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
MMDB
UniProtKB/TrEMBL
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| Article
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 740-8 (2003)
Article DOI: 10.1124/jpet.102.045799
BindingDB Entry DOI: 10.7270/Q2N878C5 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1/2B
(Homo sapiens (Human)) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| PDB
Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GluN1/GluN2B receptor (unknown origin) expressed in HEK293 cells by patch-clamp method |
Eur J Med Chem 180: 613-626 (2019)
Article DOI: 10.1016/j.ejmech.2019.07.051
BindingDB Entry DOI: 10.7270/Q2P55RRD |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z
BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| PDB
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PubMed
| 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z
BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| 1.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z
BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| 1.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z
BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| 2.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z
BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50062599
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2 |TLB:7:1:4.5.8:11,10:9:4:2.7.1,0:1:4:8.9.11,THB:7:5:11:2.1.12,12:1:4:8.9.11,12:9:4:2.7.1,6:5:11:2.1.12| Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 | PDB
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| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation counting |
J Med Chem 55: 9708-21 (2012)
Article DOI: 10.1021/jm3009458
BindingDB Entry DOI: 10.7270/Q2VQ33TR |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
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