Found 3 hits of ki for monomerid = 50203558 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203558
(4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)C(=O)NC3CN4CCC3CC4)Cc2cc1OC |w:23.24,TEB:22:23:26.27:30.29,(16.31,-37.39,;14.97,-38.15,;13.64,-37.38,;12.31,-38.14,;10.99,-37.37,;9.65,-38.14,;8.33,-37.37,;8.32,-35.83,;6.99,-35.06,;6.99,-33.52,;5.66,-32.75,;5.66,-31.2,;6.99,-30.43,;6.98,-28.9,;5.64,-28.13,;8.32,-31.2,;9.8,-30.71,;10.72,-31.96,;9.81,-33.22,;8.33,-32.75,;12.26,-31.95,;13.03,-33.28,;13.02,-30.61,;14.56,-30.63,;15.38,-31.75,;16.42,-30.44,;17.92,-30.34,;17.02,-29.25,;15.54,-29.36,;14.82,-27.89,;15.74,-28.65,;9.66,-35.05,;10.99,-35.83,;12.32,-35.07,;13.64,-35.84,;14.98,-35.08,;16.31,-35.85,)| Show InChI InChI=1S/C29H35N3O5/c1-34-24-5-4-20(15-32-11-8-19-12-25(35-2)26(36-3)13-21(19)16-32)22-14-27(37-28(22)24)29(33)30-23-17-31-9-6-18(23)7-10-31/h4-5,12-14,18,23H,6-11,15-17H2,1-3H3,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094 BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50203558
(4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)C(=O)NC3CN4CCC3CC4)Cc2cc1OC |w:23.24,TEB:22:23:26.27:30.29,(16.31,-37.39,;14.97,-38.15,;13.64,-37.38,;12.31,-38.14,;10.99,-37.37,;9.65,-38.14,;8.33,-37.37,;8.32,-35.83,;6.99,-35.06,;6.99,-33.52,;5.66,-32.75,;5.66,-31.2,;6.99,-30.43,;6.98,-28.9,;5.64,-28.13,;8.32,-31.2,;9.8,-30.71,;10.72,-31.96,;9.81,-33.22,;8.33,-32.75,;12.26,-31.95,;13.03,-33.28,;13.02,-30.61,;14.56,-30.63,;15.38,-31.75,;16.42,-30.44,;17.92,-30.34,;17.02,-29.25,;15.54,-29.36,;14.82,-27.89,;15.74,-28.65,;9.66,-35.05,;10.99,-35.83,;12.32,-35.07,;13.64,-35.84,;14.98,-35.08,;16.31,-35.85,)| Show InChI InChI=1S/C29H35N3O5/c1-34-24-5-4-20(15-32-11-8-19-12-25(35-2)26(36-3)13-21(19)16-32)22-14-27(37-28(22)24)29(33)30-23-17-31-9-6-18(23)7-10-31/h4-5,12-14,18,23H,6-11,15-17H2,1-3H3,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094 BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this Ligand-Target Pair | |
Alpha-2B adrenergic receptor
(Homo sapiens (Human)) | BDBM50203558
(4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)C(=O)NC3CN4CCC3CC4)Cc2cc1OC |w:23.24,TEB:22:23:26.27:30.29,(16.31,-37.39,;14.97,-38.15,;13.64,-37.38,;12.31,-38.14,;10.99,-37.37,;9.65,-38.14,;8.33,-37.37,;8.32,-35.83,;6.99,-35.06,;6.99,-33.52,;5.66,-32.75,;5.66,-31.2,;6.99,-30.43,;6.98,-28.9,;5.64,-28.13,;8.32,-31.2,;9.8,-30.71,;10.72,-31.96,;9.81,-33.22,;8.33,-32.75,;12.26,-31.95,;13.03,-33.28,;13.02,-30.61,;14.56,-30.63,;15.38,-31.75,;16.42,-30.44,;17.92,-30.34,;17.02,-29.25,;15.54,-29.36,;14.82,-27.89,;15.74,-28.65,;9.66,-35.05,;10.99,-35.83,;12.32,-35.07,;13.64,-35.84,;14.98,-35.08,;16.31,-35.85,)| Show InChI InChI=1S/C29H35N3O5/c1-34-24-5-4-20(15-32-11-8-19-12-25(35-2)26(36-3)13-21(19)16-32)22-14-27(37-28(22)24)29(33)30-23-17-31-9-6-18(23)7-10-31/h4-5,12-14,18,23H,6-11,15-17H2,1-3H3,(H,30,33) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 857 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094 BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this Ligand-Target Pair | |