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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'C-Raf (Y340D/Y341D)' and Ligand = 'BDBM186820'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM186820
PNG
(US9670203, Compound 1.12)
Show SMILES Fc1c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cccc1C(F)(F)F |r|
Show InChI InChI=1/C25H18F4N4O4/c26-20-14(25(27,28)29)2-1-3-15(20)31-24(35)33-21-19-13-10-11(4-6-16(13)37-22(19)21)36-17-8-9-30-23-12(17)5-7-18(34)32-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,30,32,34)(H2,31,33,35)/t19-,21-,22-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.10E+3n/an/an/an/an/a25



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)


Article DOI: 10.1021/jm960802y
More data for this
Ligand-Target Pair