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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Flap endonuclease 1 (hFEN1-336Δ)' and Ligand = 'BDBM197161'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Flap endonuclease 1 (hFEN1-336Δ)


(Homo sapiens (Human))
BDBM197161
PNG
(1-(cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,...)
Show SMILES On1c(=O)n(CC2CC2)c2ccccc2c1=O
Show InChI InChI=1S/C12H12N2O3/c15-11-9-3-1-2-4-10(9)13(7-8-5-6-8)12(16)14(11)17/h1-4,8,17H,5-7H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 30n/an/an/an/a7.5n/a



University of Sheffield



Assay Description
Reaction mixtures containing twelve different concentrations of FAM-labeled DF1 (Supplementary Fig. 5a) substrate were prepared in reaction buffer (R...


Nat Chem Biol 12: 815-21 (2016)


Article DOI: 10.1038/nchembio.2148
BindingDB Entry DOI: 10.7270/Q2RJ4H88
More data for this
Ligand-Target Pair