new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'HIV-1 Reverse Transcriptase' and Ligand = 'BDBM2134'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2134
PNG
(1-(4-chloro-1,2-dihydropyridazin-1-yl)-3-[2-(2-cya...)
Show SMILES COc1ccc(F)c(CCNC(=S)NN2C=CC(Cl)C=N2)c1C#N |c:15,19|
Show InChI InChI=1S/C15H15ClFN5OS/c1-23-14-3-2-13(17)11(12(14)8-18)4-6-19-15(24)21-22-7-5-10(16)9-20-22/h2-3,5,7,9-10H,4,6H2,1H3,(H2,19,21,24)
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 4261-74 (1996)


Article DOI: 10.1021/jm950639r
BindingDB Entry DOI: 10.7270/Q2542KSN
More data for this
Ligand-Target Pair