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Found 1 hit Enz. Inhib. hit(s) with Target = 'KCNQ (Kv7) potassium channel' and Ligand = 'BDBM50395499'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395499
PNG
(CHEMBL2163661)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H26N2O2/c1-3-18(16-10-12-17(25-2)13-11-16)21(24)22-19-8-4-5-9-20(19)23-14-6-7-15-23/h4-5,8-13,18H,3,6-7,14-15H2,1-2H3,(H,22,24)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
More data for this
Ligand-Target Pair