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Found 1 hit Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 (CSF-1)' and Ligand = 'BDBM97736'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97736
PNG
(US8481564, 13)
Show SMILES CS(=O)(=O)N=C1NCC(CN1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:30,(-7.73,-4.07,;-6.4,-3.3,;-6.4,-1.76,;-6.4,-4.84,;-5.07,-4.07,;-3.73,-3.3,;-2.4,-4.07,;-1.07,-3.3,;-1.07,-1.76,;-2.4,-.99,;-3.73,-1.76,;.27,-.99,;1.6,-1.76,;2.94,-.99,;2.94,.55,;4.27,1.32,;5.6,.55,;6.94,1.32,;6.37,-.78,;5.47,-2.03,;6.37,-3.27,;7.84,-2.8,;7.84,-1.26,;5.6,-4.61,;4.83,-5.94,;1.6,1.32,;.27,.55,;1.6,2.86,;2.94,3.63,;2.94,5.17,;1.6,5.94,;.27,5.17,;.27,3.63,)|
Show InChI InChI=1S/C22H25N7O3S/c1-33(31,32)29-22-25-11-16(12-26-22)15-7-8-19(18(9-15)14-5-3-2-4-6-14)28-21(30)20-24-13-17(10-23)27-20/h5,7-9,13,16H,2-4,6,11-12H2,1H3,(H,24,27)(H,28,30)(H2,25,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)

More data for this
Ligand-Target Pair