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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein arginine methyltransferase 8 (PRMT8)' and Ligand = 'BDBM50070951'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine methyltransferase 8 (PRMT8)


(Homo sapiens (Human))
BDBM50070951
PNG
(CHEMBL3409558)
Show SMILES [I-].C(CN1\C(Sc2c1ccc1ccccc21)=C\C=C\c1sc2c(ccc3ccccc23)[n+]1CCCc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C43H37N2S2/c1-3-14-32(15-4-1)18-12-30-44-38-28-26-34-20-7-9-22-36(34)42(38)46-40(44)24-11-25-41-45(31-13-19-33-16-5-2-6-17-33)39-29-27-35-21-8-10-23-37(35)43(39)47-41/h1-11,14-17,20-29H,12-13,18-19,30-31H2/q+1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.84E+4n/an/an/an/an/an/a



The University of Georgia

Curated by ChEMBL


Assay Description
Displacement of [3H]-SAM from recombinant His6-tagged PRMT8 (unknown origin) expressed in Escherichia coli BL21(DE3) incubated for 5 mins prior to H4...


J Med Chem 58: 1228-43 (2015)


Article DOI: 10.1021/jm501452j
BindingDB Entry DOI: 10.7270/Q29S1SQN
More data for this
Ligand-Target Pair