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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2 (SGLT2)' and Ligand = 'BDBM50302621'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50302621
PNG
((2S,3R,4R,5S)-2-(4-Chloro-3-(4-methoxyphenylthio)p...)
Show SMILES COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Sc2ccc(OC)cc2)c1 |r|
Show InChI InChI=1S/C19H21ClO6S/c1-24-11-4-6-12(7-5-11)27-14-9-10(3-8-13(14)20)18-16(22)15(21)17(23)19(25-2)26-18/h3-9,15-19,21-23H,1-2H3/t15-,16-,17+,18+,19?/m1/s1
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptake


J Med Chem 52: 6201-4 (2009)


Article DOI: 10.1021/jm900951n
BindingDB Entry DOI: 10.7270/Q2F76DH1
More data for this
Ligand-Target Pair