Compile Data Set for Download or QSAR

Found 209 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 9474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362645 (US10562916, Compound 207 | US9834564, Compound 207) Show SMILES Cn1c(CCc2cccc(n2)-c2cccnc2)nc2c1ccc1ncccc21 Show InChI InChI=1S/C23H19N5/c1-28-21-11-10-20-18(7-4-14-25-20)23(21)27-22(28)12-9-17-6-2-8-19(26-17)16-5-3-13-24-15-16/h2-8,10-11,13-15H,9,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362535 (US10562916, Compound 95 | US9834564, Compound 95) Show SMILES Clc1cc2nc(CCc3cnc4ccccc4n3)[nH]c2cc1Cl Show InChI InChI=1S/C17H12Cl2N4/c18-11-7-15-16(8-12(11)19)23-17(22-15)6-5-10-9-20-13-3-1-2-4-14(13)21-10/h1-4,7-9H,5-6H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362559 (US10562916, Compound 119 | US9834564, Compound 119) Show SMILES C(Cc1cnc2ccccc2n1)c1cn2ccccc2n1 Show InChI InChI=1S/C17H14N4/c1-2-6-16-15(5-1)18-11-13(19-16)8-9-14-12-21-10-4-3-7-17(21)20-14/h1-7,10-12H,8-9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362590 (US10562916, Compound 150 | US9834564, Compound 150) Show SMILES Cn1cc(nc1CCc1cccc(n1)-n1ccnc1)-c1ccccc1 Show InChI InChI=1S/C20H19N5/c1-24-14-18(16-6-3-2-4-7-16)23-19(24)11-10-17-8-5-9-20(22-17)25-13-12-21-15-25/h2-9,12-15H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362608 (US10562916, Compound 168 | US9834564, Compound 168) Show SMILES Cc1cnc(C)c2nc(CCc3ccc4ccc5OCCNc5c4n3)nn12 Show InChI InChI=1S/C20H20N6O/c1-12-11-22-13(2)20-24-17(25-26(12)20)8-6-15-5-3-14-4-7-16-19(18(14)23-15)21-9-10-27-16/h3-5,7,11,21H,6,8-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362540 (US10562916, Compound 100 | US9834564, Compound 100) Show SMILES CC(C)(C)c1ccc2nc(CCc3cnc4ccccc4n3)[nH]c2c1 Show InChI InChI=1S/C21H22N4/c1-21(2,3)14-8-10-18-19(12-14)25-20(24-18)11-9-15-13-22-16-6-4-5-7-17(16)23-15/h4-8,10,12-13H,9,11H2,1-3H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362592 (US10562916, Compound 152 | US9834564, Compound 152) Show SMILES Cn1cc(nc1CCc1cccc(n1)-c1ccncc1)-c1ccccc1 Show InChI InChI=1S/C22H20N4/c1-26-16-21(17-6-3-2-4-7-17)25-22(26)11-10-19-8-5-9-20(24-19)18-12-14-23-15-13-18/h2-9,12-16H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362461 (US10562916, Compound 21 | US9834564, Compound 21) Show SMILES O=c1[nH]c(CCc2nc3ccccc3[nH]2)nc2ccccc12 Show InChI InChI=1S/C17H14N4O/c22-17-11-5-1-2-6-12(11)18-16(21-17)10-9-15-19-13-7-3-4-8-14(13)20-15/h1-8H,9-10H2,(H,19,20)(H,18,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362497 (US10562916, Compound 57 | US9834564, Compound 57) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccncc2)nc2ccccc12 Show InChI InChI=1S/C18H15N5O/c24-18-13-3-1-2-4-14(13)21-17(23-18)6-5-16-20-11-15(22-16)12-7-9-19-10-8-12/h1-4,7-11H,5-6H2,(H,20,22)(H,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362557 (US10562916, Compound 117 | US9834564, Compound 117) Show SMILES C(Cc1cnc2ccccc2n1)c1nc2ccccc2s1 Show InChI InChI=1S/C17H13N3S/c1-2-6-14-13(5-1)18-11-12(19-14)9-10-17-20-15-7-3-4-8-16(15)21-17/h1-8,11H,9-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362633 (US10562916, Compound 195 | US9834564, Compound 195) Show SMILES C(Cc1ccc2cccnc2n1)c1cn2ccc3ncccc3c2n1 Show InChI InChI=1S/C20H15N5/c1-3-14-5-6-15(23-19(14)22-11-1)7-8-16-13-25-12-9-18-17(20(25)24-16)4-2-10-21-18/h1-6,9-13H,7-8H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362533 (US10562916, Compound 93 | US9834564, Compound 93) Show SMILES Cc1cc2nc(CCc3cnc4ccccc4n3)[nH]c2cc1C Show InChI InChI=1S/C19H18N4/c1-12-9-17-18(10-13(12)2)23-19(22-17)8-7-14-11-20-15-5-3-4-6-16(15)21-14/h3-6,9-11H,7-8H2,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362471 (US10562916, Compound 31 | US9834564, Compound 31) Show SMILES C(Cc1ccccc1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C17H16N2/c1-3-7-14(8-4-1)11-12-17-18-13-16(19-17)15-9-5-2-6-10-15/h1-10,13H,11-12H2,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362505 (US10562916, Compound 65 | US9834564, Compound 65) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccc3OCOc3c2)nc2ccccc12 Show InChI InChI=1S/C20H16N4O3/c25-20-13-3-1-2-4-14(13)22-19(24-20)8-7-18-21-10-15(23-18)12-5-6-16-17(9-12)27-11-26-16/h1-6,9-10H,7-8,11H2,(H,21,23)(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362508 (US10562916, Compound 68 | US9834564, Compound 68) Show SMILES C(Cc1ccc2ccccc2n1)c1nc(c[nH]1)-c1ccncc1 Show InChI InChI=1S/C19H16N4/c1-2-4-17-14(3-1)5-6-16(22-17)7-8-19-21-13-18(23-19)15-9-11-20-12-10-15/h1-6,9-13H,7-8H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362538 (US10562916, Compound 98 | US9834564, Compound 98) Show SMILES C(Cc1cnc2ccccc2n1)c1nc2cc3OCOc3cc2[nH]1 Show InChI InChI=1S/C18H14N4O2/c1-2-4-13-12(3-1)19-9-11(20-13)5-6-18-21-14-7-16-17(24-10-23-16)8-15(14)22-18/h1-4,7-9H,5-6,10H2,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362551 (US10562916, Compound 111 | US9834564, Compound 111) Show SMILES O=c1[nH]c(CCc2nc(c(o2)-c2ccccc2)-c2ccccc2)nc2ccccc12 Show InChI InChI=1S/C25H19N3O2/c29-25-19-13-7-8-14-20(19)26-21(27-25)15-16-22-28-23(17-9-3-1-4-10-17)24(30-22)18-11-5-2-6-12-18/h1-14H,15-16H2,(H,26,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362558 (US10562916, Compound 118 | US9834564, Compound 118) Show SMILES C(Cc1cnc2ccccc2n1)c1cnc2ccccc2n1 Show InChI InChI=1S/C18H14N4/c1-3-7-17-15(5-1)19-11-13(21-17)9-10-14-12-20-16-6-2-4-8-18(16)22-14/h1-8,11-12H,9-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362443 (US10562916, Compound 10 | US9834564, Compound 10) Show SMILES Cn1c(CCc2nc(c[nH]2)-c2ccccc2)nc2ccccc2c1=O Show InChI InChI=1S/C20H18N4O/c1-24-19(23-16-10-6-5-9-15(16)20(24)25)12-11-18-21-13-17(22-18)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362463 (US10562916, Compound 23 | US9834564, Compound 23) Show SMILES Cn1c(\C=C\c2nc3ccccc3c(=O)[nH]2)nc2ccccc12 Show InChI InChI=1S/C18H14N4O/c1-22-15-9-5-4-8-14(15)20-17(22)11-10-16-19-13-7-3-2-6-12(13)18(23)21-16/h2-11H,1H3,(H,19,21,23)/b11-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362481 (US10562916, Compound 41 | US9834564, Compound 41) Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccncc1 Show InChI InChI=1S/C20H18N4/c1-24-14-19(16-10-12-21-13-11-16)23-20(24)9-8-17-7-6-15-4-2-3-5-18(15)22-17/h2-7,10-14H,8-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362495 (US10562916, Compound 55 | US9834564, Compound 55) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2cccc3ccccc23)nc2ccccc12 Show InChI InChI=1S/C23H18N4O/c28-23-18-9-3-4-11-19(18)25-22(27-23)13-12-21-24-14-20(26-21)17-10-5-7-15-6-1-2-8-16(15)17/h1-11,14H,12-13H2,(H,24,26)(H,25,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362536 (US10562916, Compound 96 | US9834564, Compound 96) Show SMILES COc1cc2nc(CCc3cnc4ccccc4n3)[nH]c2cc1OC Show InChI InChI=1S/C19H18N4O2/c1-24-17-9-15-16(10-18(17)25-2)23-19(22-15)8-7-12-11-20-13-5-3-4-6-14(13)21-12/h3-6,9-11H,7-8H2,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362555 (US10562916, Compound 115 | US9834564, Compound 115) Show SMILES O=c1[nH]c(CCc2nnc([nH]2)-c2ccncc2)nc2ccccc12 Show InChI InChI=1S/C17H14N6O/c24-17-12-3-1-2-4-13(12)19-14(21-17)5-6-15-20-16(23-22-15)11-7-9-18-10-8-11/h1-4,7-10H,5-6H2,(H,19,21,24)(H,20,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362466 (US10562916, Compound 26 | US9834564, Compound 26) Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2ccccc12 Show InChI InChI=1S/C18H16N4/c1-22-17-9-5-4-8-16(17)21-18(22)11-10-13-12-19-14-6-2-3-7-15(14)20-13/h2-9,12H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362494 (US10562916, Compound 54 | US9834564, Compound 54) Show SMILES Clc1ccc(cc1)-c1c[nH]c(CCc2nc3ccccc3c(=O)[nH]2)n1 Show InChI InChI=1S/C19H15ClN4O/c20-13-7-5-12(6-8-13)16-11-21-17(23-16)9-10-18-22-15-4-2-1-3-14(15)19(25)24-18/h1-8,11H,9-10H2,(H,21,23)(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362537 (US10562916, Compound 97 | US9834564, Compound 97) Show SMILES Fc1cc2nc(CCc3cnc4ccccc4n3)[nH]c2cc1F Show InChI InChI=1S/C17H12F2N4/c18-11-7-15-16(8-12(11)19)23-17(22-15)6-5-10-9-20-13-3-1-2-4-14(13)21-10/h1-4,7-9H,5-6H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362544 (US10562916, Compound 104 | US9834564, Compound 104) Show SMILES FC(F)(F)c1ccc2[nH]c(CCc3cnc4ccccc4n3)nc2c1 Show InChI InChI=1S/C18H13F3N4/c19-18(20,21)11-5-7-15-16(9-11)25-17(24-15)8-6-12-10-22-13-3-1-2-4-14(13)23-12/h1-5,7,9-10H,6,8H2,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362579 (US10562916, Compound 139 | US9834564, Compound 139) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccncc4n3)nc12 Show InChI InChI=1S/C17H16N6/c1-11-9-19-12(2)17-21-16(22-23(11)17)6-5-14-4-3-13-7-8-18-10-15(13)20-14/h3-4,7-10H,5-6H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362602 (US10562916, Compound 162 | US9834564, Compound 162) Show SMILES COc1cccc2ccc(CCc3ccc4ccc5cccnc5c4n3)nc12 Show InChI InChI=1S/C24H19N3O/c1-28-21-6-2-4-16-9-11-19(26-22(16)21)13-14-20-12-10-18-8-7-17-5-3-15-25-23(17)24(18)27-20/h2-12,15H,13-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362430 (US10562916, Compound 14 | US9834564, Compound 3) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)nc2ccccc12 Show InChI InChI=1S/C19H16N4O/c24-19-14-8-4-5-9-15(14)21-18(23-19)11-10-17-20-12-16(22-17)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,22)(H,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362521 (US10562916, Compound 81 | US9834564, Compound 81) Show SMILES C(Cc1cnc2ccccc2n1)c1cccc(n1)-c1ccccc1 Show InChI InChI=1S/C21H17N3/c1-2-7-16(8-3-1)19-12-6-9-17(23-19)13-14-18-15-22-20-10-4-5-11-21(20)24-18/h1-12,15H,13-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362553 (US10562916, Compound 113 | US9834564, Compound 113) Show SMILES O=c1[nH]c(CCc2cc(no2)-c2ccccc2)nc2ccccc12 Show InChI InChI=1S/C19H15N3O2/c23-19-15-8-4-5-9-16(15)20-18(21-19)11-10-14-12-17(22-24-14)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362547 (US10562916, Compound 107 | US9834564, Compound 107) Show SMILES C(Cc1cnc2ccccc2n1)c1nc2ccccc2o1 Show InChI InChI=1S/C17H13N3O/c1-2-6-14-13(5-1)18-11-12(19-14)9-10-17-20-15-7-3-4-8-16(15)21-17/h1-8,11H,9-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362562 (US10562916, Compound 122 | US9834564, Compound 122) Show SMILES C(Sc1nc(c[nH]1)-c1ccccc1)c1cnc2ccccc2n1 Show InChI InChI=1S/C18H14N4S/c1-2-6-13(7-3-1)17-11-20-18(22-17)23-12-14-10-19-15-8-4-5-9-16(15)21-14/h1-11H,12H2,(H,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362609 (US10562916, Compound 169 | US9834564, Compound 169) Show SMILES Cc1cc2n(C)c(CCc3ccc4ccccc4n3)nc2c2cccnc12 Show InChI InChI=1S/C23H20N4/c1-15-14-20-23(18-7-5-13-24-22(15)18)26-21(27(20)2)12-11-17-10-9-16-6-3-4-8-19(16)25-17/h3-10,13-14H,11-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362440 (US10562916, Compound 7 | US9834564, Compound 7) Show SMILES COc1cc2nc(CCc3nc(c[nH]3)-c3ccccc3)[nH]c(=O)c2cc1OC Show InChI InChI=1S/C21H20N4O3/c1-27-17-10-14-15(11-18(17)28-2)23-20(25-21(14)26)9-8-19-22-12-16(24-19)13-6-4-3-5-7-13/h3-7,10-12H,8-9H2,1-2H3,(H,22,24)(H,23,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362464 (US10562916, Compound 24 | US9834564, Compound 24) Show SMILES Cn1c(CCc2nc3ccccc3c(=O)[nH]2)nc2ccccc12 Show InChI InChI=1S/C18H16N4O/c1-22-15-9-5-4-8-14(15)20-17(22)11-10-16-19-13-7-3-2-6-12(13)18(23)21-16/h2-9H,10-11H2,1H3,(H,19,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362477 (US10562916, Compound 37 | US9834564, Compound 37) Show SMILES O=c1[nH]c(CCc2ccc(s2)-c2ccccc2)nc2ccccc12 Show InChI InChI=1S/C20H16N2OS/c23-20-16-8-4-5-9-17(16)21-19(22-20)13-11-15-10-12-18(24-15)14-6-2-1-3-7-14/h1-10,12H,11,13H2,(H,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362475 (US10562916, Compound 35 | US9834564, Compound 35) Show SMILES C(Cc1ccc2ccccc2c1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C21H18N2/c1-2-7-18(8-3-1)20-15-22-21(23-20)13-11-16-10-12-17-6-4-5-9-19(17)14-16/h1-10,12,14-15H,11,13H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362473 (US10562916, Compound 33 | US9834564, Compound 33) Show SMILES C(Cc1ccccn1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C16H15N3/c1-2-6-13(7-3-1)15-12-18-16(19-15)10-9-14-8-4-5-11-17-14/h1-8,11-12H,9-10H2,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362550 (US10562916, Compound 110 | US9834564, Compound 110) Show SMILES O=c1[nH]c(CCc2ncc(o2)-c2ccccc2)nc2ccccc12 Show InChI InChI=1S/C19H15N3O2/c23-19-14-8-4-5-9-15(14)21-17(22-19)10-11-18-20-12-16(24-18)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362433 (US10562916, Compound 6 | US9834564, Compound 6) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)nc2cc3ccccc3cc12 Show InChI InChI=1S/C23H18N4O/c28-23-18-12-16-8-4-5-9-17(16)13-19(18)25-22(27-23)11-10-21-24-14-20(26-21)15-6-2-1-3-7-15/h1-9,12-14H,10-11H2,(H,24,26)(H,25,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362472 (US10562916, Compound 32 | US9834564, Compound 32) Show SMILES C(=C/c1ccccn1)\c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C16H13N3/c1-2-6-13(7-3-1)15-12-18-16(19-15)10-9-14-8-4-5-11-17-14/h1-12H,(H,18,19)/b10-9+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362503 (US10562916, Compound 63 | US9834564, Compound 63) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccc(cc2)-c2ccccc2)nc2ccccc12 Show InChI InChI=1S/C25H20N4O/c30-25-20-8-4-5-9-21(20)27-24(29-25)15-14-23-26-16-22(28-23)19-12-10-18(11-13-19)17-6-2-1-3-7-17/h1-13,16H,14-15H2,(H,26,28)(H,27,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362549 (US10562916, Compound 109 | US9834564, Compound 109) Show SMILES O=c1[nH]c(CCc2nc3ccccc3o2)nc2ccccc12 Show InChI InChI=1S/C17H13N3O2/c21-17-11-5-1-2-6-12(11)18-15(20-17)9-10-16-19-13-7-3-4-8-14(13)22-16/h1-8H,9-10H2,(H,18,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362591 (US10562916, Compound 151 | US9834564, Compound 151) Show SMILES Cn1cc(nc1CCc1cccc(n1)C(N)=O)-c1ccccc1 Show InChI InChI=1S/C18H18N4O/c1-22-12-16(13-6-3-2-4-7-13)21-17(22)11-10-14-8-5-9-15(20-14)18(19)23/h2-9,12H,10-11H2,1H3,(H2,19,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362469 (US10562916, Compound 29 | US9834564, Compound 29) Show SMILES C(Cc1nc(c[nH]1)-c1ccccc1)c1cccs1 Show InChI InChI=1S/C15H14N2S/c1-2-5-12(6-3-1)14-11-16-15(17-14)9-8-13-7-4-10-18-13/h1-7,10-11H,8-9H2,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362520 (US10562916, Compound 80 | US9834564, Compound 80) Show SMILES C(Cc1cnc2ccccc2n1)c1cnc(o1)-c1ccccc1 Show InChI InChI=1S/C19H15N3O/c1-2-6-14(7-3-1)19-21-13-16(23-19)11-10-15-12-20-17-8-4-5-9-18(17)22-15/h1-9,12-13H,10-11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362613 (US10562916, Compound 173 | US9834564, Compound 173) Show SMILES Cc1ccc(cn1)-c1cn(C)c(CCc2cnc3ccccc3n2)n1 Show InChI InChI=1S/C20H19N5/c1-14-7-8-15(11-21-14)19-13-25(2)20(24-19)10-9-16-12-22-17-5-3-4-6-18(17)23-16/h3-8,11-13H,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair

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