BindingDB PrimarySearch

Found 14 hits of ic50 for monomerid = 10622
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Acetylcholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
National Institutes of Health					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...				J Med Chem 49: 2174-85 (2006) Article DOI: 10.1021/jm050578p BindingDB Entry DOI: 10.7270/Q2S75DJ6
National Institutes of Health					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Aging Intramural Research Program Curated by ChEMBL					Assay Description Ability to inhibit acetylcholinesterase (AChE), freshly prepared from human erythrocytes				J Med Chem 42: 1855-61 (1999) Article DOI: 10.1021/jm980459s BindingDB Entry DOI: 10.7270/Q22N51GC
					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Aging Curated by ChEMBL					Assay Description Inhibition of human whole RBC AChE pretreated for 30 mins by Ellman technique				Bioorg Med Chem 18: 4687-93 (2011) Article DOI: 10.1016/j.bmc.2010.05.022 BindingDB Entry DOI: 10.7270/Q2KS6SHB
National Institute on Aging Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Aging Curated by ChEMBL					Assay Description Inhibition of human acetylcholinesterase from erythrocytes (RBC)				J Med Chem 40: 2895-901 (1997) Article DOI: 10.1021/jm970210v BindingDB Entry DOI: 10.7270/Q20V8BW2
National Institute on Aging Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	8.0	37
University of North Carolina at Chapel Hill					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...				J Med Chem 41: 2371-9 (1998) Article DOI: 10.1021/jm9800494 BindingDB Entry DOI: 10.7270/Q2W0944J
University of North Carolina at Chapel Hill					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28.3	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of AChE in Wistar rat brain homogenate using acetylthiocholine iodide as substrate after 0.5 hrs by Ellman's method				Bioorg Med Chem 20: 4901-14 (2012) Article DOI: 10.1016/j.bmc.2012.06.048 BindingDB Entry DOI: 10.7270/Q2W66MVP
Meiji Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Harvard University Curated by ChEMBL					Assay Description Inhibition acetylcholinesterase (AChE) enzyme.				J Med Chem 40: 4360-71 (1998) Article DOI: 10.1021/jm970488n BindingDB Entry DOI: 10.7270/Q2BZ6784
Harvard University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibitory activity against Acetylcholinesterase				J Med Chem 39: 5064-71 (1997) Article DOI: 10.1021/jm950771r BindingDB Entry DOI: 10.7270/Q2PZ59GC
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Aging Curated by ChEMBL					Assay Description Inhibition of human Butyrylcholinesterase				J Med Chem 40: 2895-901 (1997) Article DOI: 10.1021/jm970210v BindingDB Entry DOI: 10.7270/Q20V8BW2
National Institute on Aging Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...				J Med Chem 41: 2371-9 (1998) Article DOI: 10.1021/jm9800494 BindingDB Entry DOI: 10.7270/Q2W0944J
University of North Carolina at Chapel Hill					More data for this Ligand-Target Pair
Cholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Aging Intramural Research Program Curated by ChEMBL					Assay Description Ability to inhibit butyrylcholinesterase (BChE), freshly prepared from human plasma				J Med Chem 42: 1855-61 (1999) Article DOI: 10.1021/jm980459s BindingDB Entry DOI: 10.7270/Q22N51GC
					More data for this Ligand-Target Pair
Cholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institutes of Health					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...				J Med Chem 49: 2174-85 (2006) Article DOI: 10.1021/jm050578p BindingDB Entry DOI: 10.7270/Q2S75DJ6
National Institutes of Health					More data for this Ligand-Target Pair
Cholinesterase (Homo sapiens (Human))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Aging Curated by ChEMBL					Assay Description Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique				Bioorg Med Chem 18: 4687-93 (2011) Article DOI: 10.1016/j.bmc.2010.05.022 BindingDB Entry DOI: 10.7270/Q2KS6SHB
National Institute on Aging Curated by ChEMBL					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rattus norvegicus (rat))	BDBM10622 ((-)-Phenserine \| (3aS)-1,3a,8-trimethyl-1H,2H,3H,3...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of BuChE in Wistar rat plasma using acetylthiocholine iodide as substrate after 0.5 hrs by Ellman's method				Bioorg Med Chem 20: 4901-14 (2012) Article DOI: 10.1016/j.bmc.2012.06.048 BindingDB Entry DOI: 10.7270/Q2W66MVP
Meiji Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair