Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM10857 (4-aminobenzene-1-sulfonamide | CHEMBL21 | Sulfanil...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.55E+3 | n/a | n/a | n/a | n/a | n/a |
Istituto Italiano di Tecnologia Curated by ChEMBL | Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR... | J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Protein argonaute-2 (Homo sapiens) | BDBM10857 (4-aminobenzene-1-sulfonamide | CHEMBL21 | Sulfanil...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human Argonaut protein 2 PAZ domain assessed as dissociation constant by using isothermal titration microcalorimetry | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127637 BindingDB Entry DOI: 10.7270/Q2HQ43H0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Bos taurus) | BDBM10857 (4-aminobenzene-1-sulfonamide | CHEMBL21 | Sulfanil...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.88E+3 | n/a | n/a | n/a | n/a | n/a |
Istituto Italiano di Tecnologia Curated by ChEMBL | Assay Description Binding affinity to bovine carbonic anhydrase-2 assessed as dissociation constant by SPR method | J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2 | |||||||||||
More data for this Ligand-Target Pair |