Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phospholipase D1 (Homo sapiens (Human)) | BDBM123744 (5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | 37 |
Vanderbilt University | Assay Description PLD in vitro enzymatic assay using phospholipase D1(PLD1). | Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM123744 (5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | 37 |
University of Massachusetts Boston | Assay Description PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions... | Chem Biol Drug Des 84: 270-81 (2014) Article DOI: 10.1111/cbdd.12319 BindingDB Entry DOI: 10.7270/Q2HT2N05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D1 (Homo sapiens (Human)) | BDBM123744 (5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | 37 |
Vanderbilt University | Assay Description PLD in vitro enzymatic assay using phospholipase D2(PLD2). | Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM123744 (5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PLD2 | Bioorg Med Chem Lett 17: 2310-1 (2007) Article DOI: 10.1016/j.bmcl.2007.01.059 BindingDB Entry DOI: 10.7270/Q21G0KXW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D1 (Homo sapiens (Human)) | BDBM123744 (5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | 37 |
University of Massachusetts Boston | Assay Description PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions... | Chem Biol Drug Des 84: 270-81 (2014) Article DOI: 10.1111/cbdd.12319 BindingDB Entry DOI: 10.7270/Q2HT2N05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D1 (Homo sapiens (Human)) | BDBM123744 (5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | 37 |
Vanderbilt University | Assay Description Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311 | Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D (Streptomyces sp. PMF) | BDBM123744 (5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | 37 |
University of Massachusetts Boston | Assay Description PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions... | Chem Biol Drug Des 84: 270-81 (2014) Article DOI: 10.1111/cbdd.12319 BindingDB Entry DOI: 10.7270/Q2HT2N05 | |||||||||||
More data for this Ligand-Target Pair |