Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM13775 ((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a |
ALLERGAN, INC. US Patent | Assay Description Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS... | US Patent US10188667 (2019) BindingDB Entry DOI: 10.7270/Q24Q7X38 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho GTPase-activating protein 35 (Homo sapiens (Human)) | BDBM13775 ((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 41.6 | n/a | n/a | n/a | n/a |
ALLERGAN, INC. US Patent | Assay Description Glucocorticoid receptor (GR) activation potency was assessed using a HeLa cell line containing the MMTV-bla reporter (MMTV-bla HeLa CELLSENSOR®, Invi... | US Patent US10188667 (2019) BindingDB Entry DOI: 10.7270/Q24Q7X38 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (RAT) | BDBM13775 ((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00299 BindingDB Entry DOI: 10.7270/Q2N87FSM | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glucocorticoid receptor (RAT) | BDBM13775 ((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induct... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00379 BindingDB Entry DOI: 10.7270/Q2VM4H3N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |