Compile Data Set for Download or QSAR

Found 18 hits of ki for monomerid = 143747   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...				US Patent US9845333 (2017) BindingDB Entry DOI: 10.7270/Q21838TW
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	-9.91	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM 001525) or Chinese ovary cells (CHO) ...				US Patent US8969352 (2015) BindingDB Entry DOI: 10.7270/Q2FB51PC
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description CHO cells stably transfected with the human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12, 10% FBS, 1×...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description CHO cells stably transfected with the human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12, 10% FBS, 1×...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	-9.88	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM 001525) or Chinese ovary cells (CHO) ...				US Patent US8969352 (2015) BindingDB Entry DOI: 10.7270/Q2FB51PC
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...				US Patent US9845333 (2017) BindingDB Entry DOI: 10.7270/Q21838TW
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description PFSK-1 cells endogenously expressing the human orexin 2 receptor were grown to confluency in RPMI1640 (Hyclone, cat #30027.02), 10% FBS, 1× pen-strep...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description PFSK-1 cells endogenously expressing the human orexin 2 receptor were grown to confluency in RPMI1640 (Hyclone, cat #30027.02), 10% FBS, 1× pen-strep...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Rattus norvegicus (Rat))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...				US Patent US9845333 (2017) BindingDB Entry DOI: 10.7270/Q21838TW
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143747 (US10183953, Example 8 | US8969352, 8 | US9611277, ...) Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| Show InChI InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US8969352 (2015) BindingDB Entry DOI: 10.7270/Q2FB51PC
					More data for this Ligand-Target Pair