Compile Data Set for Download or QSAR

Found 18 hits of ki for monomerid = 143752   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	52	-9.23	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM 001525) or Chinese ovary cells (CHO) ...				US Patent US8969352 (2015) BindingDB Entry DOI: 10.7270/Q2FB51PC
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...				US Patent US9845333 (2017) BindingDB Entry DOI: 10.7270/Q21838TW
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	109	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description CHO cells stably transfected with the human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12, 10% FBS, 1×...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	109	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	109	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description CHO cells stably transfected with the human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12, 10% FBS, 1×...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	109	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	109	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...				US Patent US9845333 (2017) BindingDB Entry DOI: 10.7270/Q21838TW
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	109	-8.82	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM 001525) or Chinese ovary cells (CHO) ...				US Patent US8969352 (2015) BindingDB Entry DOI: 10.7270/Q2FB51PC
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description PFSK-1 cells endogenously expressing the human orexin 2 receptor were grown to confluency in RPMI1640 (Hyclone, cat #30027.02), 10% FBS, 1× pen-strep...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description PFSK-1 cells endogenously expressing the human orexin 2 receptor were grown to confluency in RPMI1640 (Hyclone, cat #30027.02), 10% FBS, 1× pen-strep...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Rattus norvegicus (Rat))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...				US Patent US9845333 (2017) BindingDB Entry DOI: 10.7270/Q21838TW
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM143752 (US10183953, Example 13 | US8969352, 13 | US9611277...) Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:13:12:8.9:25,6:8:12.11:25| Show InChI InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US8969352 (2015) BindingDB Entry DOI: 10.7270/Q2FB51PC
					More data for this Ligand-Target Pair