Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 92.1 | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
CoMentis, Inc. US Patent | Assay Description Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo... | US Patent US8975415 (2015) BindingDB Entry DOI: 10.7270/Q2SB44GN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 92.1 | -9.59 | 128 | n/a | n/a | n/a | n/a | 4.4 | 25 |
COMENTIS, INC. US Patent | Assay Description Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi... | US Patent US9242973 (2016) BindingDB Entry DOI: 10.7270/Q29W0D9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 113 | -9.47 | 145 | n/a | n/a | n/a | n/a | 4.4 | 25 |
COMENTIS, INC. US Patent | Assay Description Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi... | US Patent US9242973 (2016) BindingDB Entry DOI: 10.7270/Q29W0D9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 113 | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
CoMentis, Inc. US Patent | Assay Description Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo... | US Patent US8975415 (2015) BindingDB Entry DOI: 10.7270/Q2SB44GN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | 37 |
COMENTIS, INC. US Patent | Assay Description Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ production. Human SK-N-BE(2) neuroblas... | US Patent US9242973 (2016) BindingDB Entry DOI: 10.7270/Q29W0D9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | 37 |
COMENTIS, INC. US Patent | Assay Description Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ production. Human SK-N-BE(2) neuroblas... | US Patent US9242973 (2016) BindingDB Entry DOI: 10.7270/Q29W0D9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.73E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
CoMentis, Inc. US Patent | Assay Description The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut... | US Patent US8975415 (2015) BindingDB Entry DOI: 10.7270/Q2SB44GN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
COMENTIS, INC. US Patent | Assay Description Test Example 5: The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were perfor... | US Patent US9242973 (2016) BindingDB Entry DOI: 10.7270/Q29W0D9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
CoMentis, Inc. US Patent | Assay Description The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut... | US Patent US8975415 (2015) BindingDB Entry DOI: 10.7270/Q2SB44GN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM149919 (US8975415, RP200 | US8975415, RP202 | US9242973, R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
COMENTIS, INC. US Patent | Assay Description Test Example 5: The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were perfor... | US Patent US9242973 (2016) BindingDB Entry DOI: 10.7270/Q29W0D9C | |||||||||||
More data for this Ligand-Target Pair |