BindingDB PrimarySearch

Found 23 hits of ic50 for monomerid = 17657
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8				Bioorg Med Chem Lett 15: 349-51 (2004) Article DOI: 10.1016/j.bmcl.2004.10.093 BindingDB Entry DOI: 10.7270/Q2G161M2
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2020.112872 BindingDB Entry DOI: 10.7270/Q2639TV2
TBA					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	613	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Urbino Carlo Bo Curated by ChEMBL					Assay Description Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA				J Med Chem 48: 6887-96 (2005) Article DOI: 10.1021/jm058018d BindingDB Entry DOI: 10.7270/Q28C9X1X
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
TBA					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
TBA					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Excitatory amino acid transporter 4 (Rattus norvegicus)	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of rat EAAT4 transfected in human tsA201 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintill...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
TBA					More data for this Ligand-Target Pair
Excitatory amino acid transporter 4 (Rattus norvegicus)	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of rat EAAT4 transfected in human tsA201 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintill...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
TBA					More data for this Ligand-Target Pair
Excitatory amino acid transporter 4 (Rattus norvegicus)	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Excitatory amino acid transporter 4 (Rattus norvegicus)	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human EAAT3 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
TBA					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human EAAT3 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
TBA					More data for this Ligand-Target Pair
Excitatory amino acid transporter 2 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Excitatory amino acid transporter 2 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Glutathione reductase, mitochondrial (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
Batman University Curated by ChEMBL					Assay Description Inhibition of human erythrocyte Glutathione reductase				Bioorg Med Chem Lett 21: 5398-402 (2011) Article DOI: 10.1016/j.bmcl.2011.07.002 BindingDB Entry DOI: 10.7270/Q2V69KKH
Batman University Curated by ChEMBL					More data for this Ligand-Target Pair
Excitatory amino acid transporter 2 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
TBA					More data for this Ligand-Target Pair
Excitatory amino acid transporter 2 (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
TBA					More data for this Ligand-Target Pair
Glutamate carboxypeptidase 2 [44-750] (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	4.28E+5	n/a	n/a	n/a	n/a	7.4	37
NCI-FCRDC					Assay Description The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...				J Med Chem 50: 3267-73 (2007) Article DOI: 10.1021/jm070133w BindingDB Entry DOI: 10.7270/Q29C6VPS
NCI-FCRDC					More data for this Ligand-Target Pair
Alpha-ketoglutarate-dependent dioxygenase FTO (Homo sapiens (Human))	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...				J Med Chem 56: 3680-8 (2013) Article DOI: 10.1021/jm400193d BindingDB Entry DOI: 10.7270/Q21V5GBQ
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Prolyl 4-hydroxylase (Paramecium bursaria Chlorella virus 1)	BDBM17657 ((2S)-2-aminopentanedioic acid \| (S)-Glu \| D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...				Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 BindingDB Entry DOI: 10.7270/Q2KK9G4R
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair