Compile Data Set for Download or QSAR

Found 5 hits of ec50 for monomerid = 20334   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20334 (1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1 Show InChI InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	47	-9.99	n/a	n/a	11	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...				J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20334 (1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1 Show InChI InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...				Bioorg Med Chem Lett 17: 3894-9 (2007) Article DOI: 10.1016/j.bmcl.2007.04.105 BindingDB Entry DOI: 10.7270/Q2NV9GH2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20334 (1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1 Show InChI InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...				J Med Chem 48: 744-52 (2005) Article DOI: 10.1021/jm0492958 BindingDB Entry DOI: 10.7270/Q2J38QT3
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20334 (1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1 Show InChI InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.10	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...				J Med Chem 50: 3651-60 (2007) Article DOI: 10.1021/jm070276i BindingDB Entry DOI: 10.7270/Q2SJ1HWH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20334 (1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1 Show InChI InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...				J Med Chem 48: 744-52 (2005) Article DOI: 10.1021/jm0492958 BindingDB Entry DOI: 10.7270/Q2J38QT3
					More data for this Ligand-Target Pair