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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 16 | -11.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Universitat de Barcelona | Assay Description Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent... | Bioorg Med Chem 17: 7387-97 (2009) Article DOI: 10.1016/j.bmc.2009.08.006 BindingDB Entry DOI: 10.7270/Q2RR1WKS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting | J Med Chem 52: 675-87 (2009) Article DOI: 10.1021/jm8009469 BindingDB Entry DOI: 10.7270/Q2SN09V7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | 16 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a | |
Virginia Commonwealth University | Assay Description The h5-HT6 radioligand binding assays were performed as previously described. In brief, h5-HT6 cDNA was transiently expressed in HEK-293 cells using... | Medicinal Chemistry Research 14: 1-18 (2005) BindingDB Entry DOI: 10.7270/Q2NG4P78 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity against 5 Hydroxy tryptamine 6 receptor | Bioorg Med Chem Lett 15: 1707-11 (2005) Article DOI: 10.1016/j.bmcl.2005.01.031 BindingDB Entry DOI: 10.7270/Q2D21ZBG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 6 receptor | J Med Chem 46: 2795-812 (2003) Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 6 receptor | Bioorg Med Chem Lett 14: 4569-73 (2004) Article DOI: 10.1016/j.bmcl.2004.05.076 BindingDB Entry DOI: 10.7270/Q2CJ8F73 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Caen Basse-Normandie Curated by ChEMBL | Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectromet... | J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells | J Med Chem 51: 603-11 (2008) Article DOI: 10.1021/jm070910s BindingDB Entry DOI: 10.7270/Q2CJ8D84 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 6 receptor | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity for human 5-hydroxytryptamine 6 receptor expressed in HEK 293 human embryonic kidney cells, [3H]-lysergic acid diethylamide as radio... | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards human human 5-hydroxytryptamine 1A receptor | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1E (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2C (Rattus norvegicus (Rat)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 1.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2C receptor | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 4.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 5A receptor | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards human serotonin transporter | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2A receptor | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards human NET(norepinephrine) transporter | J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
