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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D3 expressed in CHO cells | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Binding affinity (high) towards human dopamine receptor 3 against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description In vitro ability to displace [3H]-spiperone from bovine cloned Dopamine receptor D2 stably expressed in CHO cells. | Bioorg Med Chem Lett 11: 2863-6 (2001) BindingDB Entry DOI: 10.7270/Q2D799Q9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description In vitro ability to displace [3H]-spiperone from human cloned Dopamine receptor D3 stably expressed in CHO cells. | Bioorg Med Chem Lett 11: 2863-6 (2001) BindingDB Entry DOI: 10.7270/Q2D799Q9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (BOVINE) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description In vitro ability to displace [3H]-Pramipexole from high affinity binding sites of bovine cloned D2 receptors stably expressed in CHO cells. | Bioorg Med Chem Lett 11: 2863-6 (2001) BindingDB Entry DOI: 10.7270/Q2D799Q9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D4.4 expressed in CHO cells | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description High binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligand | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D2S expressed in CHO cells | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description High binding affinity towards human dopamine receptor 2 (short) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligand | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description High binding affinity towards human dopamine receptor 2 (long) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligand | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D2L expressed in CHO cells | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (BOVINE) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description In vitro ability to displace [3H]-spiperone from bovine cloned Dopamine receptor D2 stably expressed in CHO cells. | Bioorg Med Chem Lett 11: 2863-6 (2001) BindingDB Entry DOI: 10.7270/Q2D799Q9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (BOVINE) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description In vitro ability to displace [3H]-spiperone from bovine cloned Dopamine receptor D2 stably expressed in CHO cells. | Bioorg Med Chem Lett 11: 2863-6 (2001) BindingDB Entry DOI: 10.7270/Q2D799Q9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D3 expressed in CHO cells | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Low binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligand | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Low binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligand | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D4.4 expressed in CHO cells | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Binding affinity (low) towards human dopamine receptor 2 short against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D2S expressed in CHO cells | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D2L expressed in CHO cells | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Binding affinity (low) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(1A) dopamine receptor (BOVINE) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Binding affinity (low) towards bovine dopamine receptor 1 by using [3H]-SCH- 23390 (0.3 nM) as radioligand | J Med Chem 48: 5771-9 (2005) Article DOI: 10.1021/jm0503805 BindingDB Entry DOI: 10.7270/Q2KW5GT9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(1A) dopamine receptor (BOVINE) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Inhibition constant against [3H]-SCH-23,390 binding to Dopamine receptor D1 in bovine striatal membranes | J Med Chem 48: 2493-508 (2005) Article DOI: 10.1021/jm049269+ BindingDB Entry DOI: 10.7270/Q2TT4QGT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(1A) dopamine receptor (BOVINE) | BDBM50105731 ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description In vitro ability to displace [3H]-SCH-23,390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells. | Bioorg Med Chem Lett 11: 2863-6 (2001) BindingDB Entry DOI: 10.7270/Q2D799Q9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
