Found 5 hits of ec50 for drug = Amidate Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABA |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a |
Universit£ di Sassari
Curated by ChEMBL
| Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse... |
J Med Chem 48: 2638-45 (2005)
Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a |
Imperial College
Curated by ChEMBL
| Assay Description Activity at human GABAA alpha1beta2gamma2s receptor expressed in HEK293 cells assessed as effect on GABA-induced current at 3 uM by whole cell patch-... |
J Biol Chem 282: 12038-47 (2007)
Article DOI: 10.1074/jbc.M700479200 BindingDB Entry DOI: 10.7270/Q29P31FP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM) |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |