Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Caspase-1 (Homo sapiens (Human)) | BDBM50284739 (3-[2-(2-Benzyloxycarbonylamino-3-methyl-butyrylami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | n/a | n/a | n/a | n/a | 1.10 | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as Kon | Bioorg Med Chem Lett 5: 1409-1414 (1995) Article DOI: 10.1016/0960-894X(95)00232-I BindingDB Entry DOI: 10.7270/Q2319VTD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50213208 (CHEMBL3143890) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | n/a | n/a | n/a | n/a | n/a | n/a | 4.30 | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound was determined against ETA receptor in porcine aortic smooth muscle membrane | Bioorg Med Chem Lett 5: 1409-1414 (1995) Article DOI: 10.1016/0960-894X(95)00232-I BindingDB Entry DOI: 10.7270/Q2319VTD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50450287 (CHEMBL31061) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | n/a | n/a | n/a | n/a | 3.40E+3 | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as Kon | Bioorg Med Chem Lett 5: 1409-1414 (1995) Article DOI: 10.1016/0960-894X(95)00232-I BindingDB Entry DOI: 10.7270/Q2319VTD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50284734 (3-Allyloxycarbonylamino-4-oxo-5-(3-phenylcarbamoyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | n/a | n/a | 4.10E+3 | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as Kon | Bioorg Med Chem Lett 5: 1409-1414 (1995) Article DOI: 10.1016/0960-894X(95)00232-I BindingDB Entry DOI: 10.7270/Q2319VTD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50284733 (3-Allyloxycarbonylamino-5-(3-cyano-naphthalen-2-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | n/a | n/a | 4.50E+3 | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as Kon | Bioorg Med Chem Lett 5: 1409-1414 (1995) Article DOI: 10.1016/0960-894X(95)00232-I BindingDB Entry DOI: 10.7270/Q2319VTD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50284735 (3-Allyloxycarbonylamino-5-(3-carbamoyl-naphthalen-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | n/a | n/a | 5.60E+3 | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as Kon | Bioorg Med Chem Lett 5: 1409-1414 (1995) Article DOI: 10.1016/0960-894X(95)00232-I BindingDB Entry DOI: 10.7270/Q2319VTD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50284744 (3-Allyloxycarbonylamino-5-[3-(1H-imidazol-2-yl)-na...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | n/a | n/a | n/a | n/a | 1.20E+4 | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as Kon | Bioorg Med Chem Lett 5: 1409-1414 (1995) Article DOI: 10.1016/0960-894X(95)00232-I BindingDB Entry DOI: 10.7270/Q2319VTD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50422308 (CHEMBL71295) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 1.17E+5 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Evaluated for kinetic dissociation constant (kon) for the inhibition of caspase-1. | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50091570 (3-[2-(2-Benzyloxycarbonylamino-3-methyl-butyrylami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 1.60E+5 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Evaluated for kinetic dissociation constant (kon) for the inhibition of caspase-1. | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50291983 (5-(4-Benzyl-5-oxo-2,5-dihydro-furan-3-yloxy)-3-[(S...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 2.52E+5 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Evaluated for kinetic dissociation constant (kon) for the inhibition of caspase-1. | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50291985 (3-{[1-(2-Benzyloxycarbonylamino-3-methyl-butyryl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 2.71E+5 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Compound was evaluated for the inhibitory activity against caspase-1 | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50291984 (3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-bu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 2.80E+5 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Compound was evaluated for the inhibitory activity against caspase-1 | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50091566 (3-(2-{2-[2-Acetylamino-3-(4-hydroxy-phenyl)-propio...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 3.80E+5 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Evaluated for kinetic dissociation constant (kon) for the inhibition of caspase-1. | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50422307 (CHEMBL273689) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 4.07E+5 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Compound was evaluated for the inhibitory activity against caspase-1 | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50091580 (3-[2-(2-Benzyloxycarbonylamino-3-methyl-butyrylami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 4.30E+5 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Evaluated for dissociation constant for the inhibition of caspase-1 | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Caspase-1 (Homo sapiens (Human)) | BDBM50091572 (3-[2-(2-Benzyloxycarbonylamino-3-methyl-butyrylami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | n/a | n/a | 1.60E+6 | n/a | n/a |
BASF Bioresearch Corporation Curated by ChEMBL | Assay Description Evaluated for dissociation constant for the inhibition of caspase. | J Med Chem 43: 3351-71 (2000) BindingDB Entry DOI: 10.7270/Q2416W98 | |||||||||||
More data for this Ligand-Target Pair |